Results 41 to 50 of about 282,859 (304)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

LncRNA GAS5 Regulates Myometrial Cell Contractions in an m6A-Dependent Manner

Function
LncRNAs are engaged in signaling pathways in human physiological and pathological states. However, LncRNAs mediate the onset of human labor still remains unknown. RNA sequencing of lower segment myometrium (in labor vs. not in labor) was analyzed.
Yue Sun, Min Zhang, Tianjun Wang, Shiyun Huang, Qing Zuo, Lanhua Liu, Runrun Feng, Yufei Han, Cen Cao, Haiyan Sun, Yihan Lu, Xinxin Zhu, Yuping Tang, Shuang Wu, Guoqiang Ping, Lizhou Sun, Zhiping Ge, Ziyan Jiang   +17 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Maternal and neonatal outcomes associated with induction of labor after one previous cesarean delivery: A French retrospective study.

PLoS ONE, 2020
BackgroundThe safety of methods of labor induction in women with previous cesarean deliveries is still debated. We investigated perinatal outcomes associated with labor induction among women with a trial of labor after one cesarean delivery.MethodsThis ...
Emma Vecchioli, Anne-Gaël Cordier, Anne Chantry, Alexandra Benachi, Isabelle Monier   +4 more
doaj   +1 more source

Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. [PDF]

, 2017
BackgroundPreterm birth is a main determinant of neonatal mortality and morbidity and a major contributor to the overall mortality and burden of disease.
Andrews, William, Baldwin, Donald A, Biggio, Joseph R, Bukowski, Radek, Esplin, Sean M, Goodarzi, Hani, Ilekis, John V, Parry, Samuel, Reddy, Uma M, Saade, George R, Sadovsky, Yoel, Varner, Michael, Xiao, Feifei, Zhang, Heping   +13 more
core   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Case of Bilateral Foot Drop Following Uncomplicated Vaginal Delivery A Case Report and Review of Literature

Amrita Journal of Medicine, 2021
Peroneal neuropathy leading to foot drop is a rare, but preventable, maternal complication following vaginal delivery. Prolonged labor and regional anesthesia during labor are major risk factors for peroneal neuropathy. Obstetric peroneal nerve injury is
Vijayan Sharmila, Arun Babu Thirunavukkarasu   +1 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Involuntary Part-time Work On The Rise [PDF]

, 2008
[Excerpt] A number of labor market indicators from the Current Population Survey (CPS) have pointed to a weakening labor market for more than a year, even before the onset of the current recession in December 2007 (as designated by the National Bureau of
Bureau of Labor Statistics
core   +1 more source

Seizure-onset mapping based on time-variant multivariate functional connectivity analysis of high-dimensional intracranial EEG : a Kalman filter approach [PDF]

, 2016
The visual interpretation of intracranial EEG (iEEG) is the standard method used in complex epilepsy surgery cases to map the regions of seizure onset targeted for resection.
Lie, Octavian V, van Mierlo, Pieter
core   +1 more source