Results 161 to 170 of about 680,920 (309)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

open access: yesAdvanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding   +5 more
wiley   +1 more source

High‐Performance Ternary Organic Solar Cells via Isomeric Engineering of Nonfullerene Guest Acceptors

open access: yesAdvanced Science, EarlyView.
Two isomeric nonfullerene acceptors, BTP‐γ‐Br and BTP‐δ‐Br, were designed to investigate their effects on the optoelectronic properties and photovoltaic performance of ternary blends. Incorporating BTP‐γ‐Br into the D18:N3 binary system can enhance film crystallinity and suppress charge recombination, achieving a high PCE of 19.2% and a certified JSC ...
Zhenzhong Pan   +8 more
wiley   +1 more source

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

open access: yesAdvanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang   +9 more
wiley   +1 more source

Determinants of Birth Asphyxia Among Newborns at a Tertiary Care Hospital, Central Ethiopia: A Case-Control Study. [PDF]

open access: yesBiomed Res Int
Alemayehu T   +6 more
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

open access: yesAdvanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi   +13 more
wiley   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

open access: yesAdvanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li   +12 more
wiley   +1 more source

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