Results 151 to 160 of about 142,827 (308)

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Association of Phenylthiocarbamide Taste Sensitivity with Dental Caries, Skeletal Maturity, and Body Mass Index Percentiles in Children Aged 8-12 Years: A Cross-sectional Study. [PDF]

Int J Clin Pediatr Dent
Dixit A, Saxena A, Verma N, Khandelwal V.   +3 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Computational Approach Improves Diagnostic Performance Based on Tumor-Associated Autoantibodies in Esophageal Squamous Cell Carcinoma. [PDF]

Comput Struct Biotechnol J
Nojima Y, Shiratori F, Suzuki T, Yajima S, Toyozumi T, Shimada H.   +5 more
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Dry Ice in Decoverslipping Microscopic Slides: A Novel Approach. [PDF]

Cureus
Pinisetti S, Dasarathi A, Jyothsna M, Shaik H, Jini J, Iqbal R.   +5 more
europepmc   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

Enhancing Communication Between Dental Laboratories and Clinics: The Role of Information Technology Systems in a Developing Country

Clinical, Cosmetic and Investigational Dentistry
Farid Tawfiq Nusairat,1 Salam Walid Al-Shogran,1 Noor Almortadi,2 Karem H Alzoubi3,4 1Department of Health Policy and Management, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Applied Dental Sciences ...
Nusairat FT, Al-Shogran SW, Almortadi N, Alzoubi KH   +3 more
doaj  

Resistance profiles of fastidious oral anaerobes and other periodontal species by multipoint inoculator: an <i>in vitro</i> study. [PDF]

Front Dent Med
Wolf A, Indra A, Heger F, Reichl J, Moritz A, Georgopoulos A.   +5 more
europepmc   +1 more source