Results 191 to 200 of about 140,314 (290)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

A Multi-Disciplinary Approach to Managing Anterior Aesthetics: Crown Lengthening/Digital Smile Design (DSD)/Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM). [PDF]

Cureus
Kouji S, El Yamani A.
europepmc   +1 more source

Mechano‐Bactericidal Surfaces Achieved by Epitaxial Growth of Metal–Organic Frameworks

Advanced Science, EarlyView.
Mechano‐bactericidal surfaces based on metal–organic frameworks (MOFs) are designed using a MOF‐on‐MOF strategy. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, are applied. Distinct mechano‐bactericidal actions are discussed, including stretching, impaling, and mechanical injury. Abstract Mechano‐bactericidal (MB) surfaces
Zhejian Cao, Santosh Pandit, Francoise M. Amombo Noa, Jian Zhang, Wengeng Gao, Shadi Rahimi, Lars Öhrström, Ivan Mijakovic   +7 more
wiley   +1 more source

Patterns of claims and determinants of claim rejections in Kuwait's National Health Insurance for Retirees (AFYA): a comprehensive analysis. [PDF]

Front Public Health
Alibrahim AI, Kelendar H, Alhenaidi A.
europepmc   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Policy and preference: the intersection of attendance hurdles and student perceptions of practical classes. [PDF]

BMC Med Educ
Donald KJ, Cochrane A, Byrne S, Cheshire L, Stander J, Clements T, Finch S, Hill N, Kefalianos E, Lees J, Maruyama M, Story L, Tarrant B, Virtue D, Haber T.   +14 more
europepmc   +1 more source

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source

X-linked hypophosphatemia and tumor-induced osteomalacia: a narrative review and expert opinion on the diagnostic and therapeutic challenges in the era of burosumab. [PDF]

Orphanet J Rare Dis
Brandi ML, Vainicher CE, Fintini D, Giusti A, Magnolato A, Minisola S, Giannini S.   +6 more
europepmc   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

Comparative Usability Evaluation of Three Digital Smile Design Software Tools Using the System Usability Scale. [PDF]

Dent J (Basel)
Macris A, Drafta S, Martiniuc Ș, Petre AE.   +3 more
europepmc   +1 more source