Results 111 to 120 of about 1,817,333 (347)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk +4 morewiley +1 more sourceEffective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet +17 morewiley +1 more sourceMonitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien +35 morewiley +1 more sourceLaboratory Animal Science – Main focus: Neuroscience [PDF]
, 2007 Jens Frahm, Oliver Natt, Takashi Watanabe, Susann Boretius, Thomas Michaelis, Walter Schulz‐Schaeffer, Christine Stadelmann, Anna‐Leena Sirén, Hannelore Ehrenreich, Maureen Walberer, Tibo Gerriets, Erwin Stolz, Manfred Kaps, Clemens Müller, A. Kluge, Anna Bachmann, Marc Fisher, Georg Bachmann, Konstanze Plaschke, Hubert J. Bardenheuer, E Rodríguez Martín, Michael Knauth, Alicia M. Mohr, Kun‐Liang Guan, V Zyba, Thomas Becker, Sehoon Won, D Lages, Arnd B. Buchwald, Gerd Hasenfuß, Sarah König, Petra Krause, Bernhard Aigner, Nikolai Klymiuk, Markus Müller, Г. Брем, Susan Compton, Felix R. Homberger, Judy Clark, F X Paturzo, Kathryn H. Jacobsen, Esther Mahabir, Markus Brielmeier, Peter Wilhelm, Kathleen Seidel, Jens Schmidt, J. R. Needham, Gerhard Heldmaier, Sascha Ott, Jürgen Löhler, K Yamamur, Kurt Reifenberg, Reinhart Kluge, Michel J. Grothe, Stephan Scherneck, K Schmolz, K. Giesen, Leona Plum, Hans‐Georg Joost, Heidi C. Meyer, Werner Nicklas, K Alekuzei, Johanna Steinke, H Schmitto, Schoendube Reconstitution, André Bleich, J. Lauber, Jan Buer, Hans J. Hedrich, Michael Mähler, Ines Bolle, Gero Hilken, Wojciech T. Chwalisz, Dirk Wedekind, Markus Heuser, Gerhard Zöller, R.‐H. Ringert, Bernhard Hemmerlein, J. Kaspareit, S. Friderichs–Gromoll, Eberhard Buse, Gunnar Habermann, F. Stephen Vogel, Matthew Klein, Taavi Tillmann, Philbert S. Tsai, H. Hackbarth, Clemens Dasenbrock, Matthew Klein, Taavi Tillmann, Christa Krüger, D. Büttner, H Böhme, Klaus Militzer, Jalaluddin Abdul Malek, Pernille Nielsen, H Mossmann, N Gerstmayr, Gabriela Spindler, Jens Brodbeck +99 moreopenalex +1 more sourceTREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde +2 morewiley +1 more sourceLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more source
