Results 261 to 270 of about 11,521,408 (419)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Chernobyl-level radiation exposure damages bumblebee reproduction: a laboratory experiment. [PDF]

Proc Biol Sci, 2020
Raines KE, Whitehorn PR, Copplestone D, Tinsley MC.   +3 more
europepmc   +1 more source

A laboratory course in serum study; bacteriology 208, being a series of experiments and diagnostic tests in immunology carried out in an optional course given to medical and graduate students in the Department of Bacteriology, College o by the writers, Hans Zinsser, M. D., J. G. Hopkins, M. D. [and] Reuben Ottenberg, M. D

, 1921
Hans Zinsser, Jill Hopkins, Reuben Ottenberg, Hans Zinsser   +3 more
openalex   +2 more sources

Determining the effects of films with suicidal content: A laboratory experiment

British Journal of Psychiatry, 2015
B. Till, Markus J. Strauss, G. Sonneck, T. Niederkrotenthaler   +3 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Global big data laboratory experiment, integrated with kernel-based algorithm with an improved nonlinear ensemble for compressive strength modeling. [PDF]

Sci Rep
Salami BA, Usman J, Gbadamosi A, Malami SI, Abba SI.   +4 more
europepmc   +1 more source

RADIATION EXCURSIONS AT THE ORNL CRITICAL EXPERIMENTS LABORATORY. I. MAY 26, 1954. II. FEBRUARY 1, 1956

, 1958
J.T. Thomas, Dixon Callihan
openalex   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

On Geostrophic Adjustment in Sea Straits and Wide Estuaries: Theory and Laboratory Experiments. Part II—Two-Layer System [PDF]

, 1978
Doron Nof
openalex   +1 more source