Results 121 to 130 of about 1,216,010 (256)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Readiness to Consider and Adopt Genetic and Genomic Tests in Canada-An Update to the State of Readiness Report. [PDF]

Curr Oncol
Husereau D, Servidio-Italiano F, D'Angelo MS, Muthu V, Mengel M, Ivany C, Steuten L, Spinner DS, Sheffield B, Yip S, Jacobs P, Arshoff L.   +11 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The need to strengthen laboratory leadership, systems, and networks to enhance outbreak detection and resilience in Africa: proceedings of a regional workshop. [PDF]

BMC Proc
Onywera H, Njouom R, Wanjohi DW, Mushumbusi JPC, Moindze A, Kebede A, Ayitewala A, Mwafulango AE, von Gottberg A, Tanui CK, Shikaseba E, Moosa F, Koukouikila-Koussounda F, Guindo I, Ssewanyana I, Bitilinyu-Bangoh J, Nyandwi J, Ndlangisa KM, Koné KM, du Plessis M, Nyenje ME, Diagne MM, Mayet NT, Dereje N, Keita NY, Bonkoungou OJI, Mbala P, Akil-Bandali P, Essomba RG, Niama RF, Chilengi R, Mwangi S, Barro S, Moyo S, Nabadda SN, Maruta T, Muyigi T, Bitoungui VJN, Ahmad U, Chibabhai V, Mokaya WK, Tadjidine Y, Tessema SK, Kaseya J, Tebeje YK.   +44 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Cross-Country Evaluation of Respiratory Syncytial Virus and Human Metapneumovirus Surveillance Systems: Identifying Gaps and Best Practices for Improved Disease Monitoring. [PDF]

Rev Med Virol
Martyn O, Devos J, Bourron P, AbouElwafa D, Vitoux O, Fougerolles TR.   +5 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

CWSS-IS: A Technical Framework for Digitalized Wastewater Surveillance-Information System Structure, Data Standards, and Application - China, February 2024-January 2026. [PDF]

China CDC Wkly
Hao S, Zhang L, Deng F, Han J, Li X, Sun H, Zhang X, Tang S, Zhang L, Yang Y, Guo Q, Wang L, Liu Y, Yao X.   +13 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source