Results 191 to 200 of about 1,216,010 (256)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Artificial Intelligence in Healthcare Administration and Clinical Informatics: A Critical Review and Governance Roadmap. [PDF]

Healthcare (Basel)
Aldosari H.
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Recommendations for HLA Genotyping Data Standards and Clinical Laboratory Staffing Considerations. [PDF]

HLA
Spierings E, Brown NK, Latham K, Robinson J, Melchers M, Askar M, Morris GP, Weimer E, Maiers M, Madbouly A.   +9 more
europepmc   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Health system strategies and responses to the effects of Climate Change in Sub-Saharan Africa: A scoping review. [PDF]

PLoS One
Chimatiro CS, Mianda S, Hajison P, Lembani M.   +3 more
europepmc   +1 more source

Why sycophantic LLMs may imperil interactive norms between humans. [PDF]

Commun Psychol
Gu R, Chen Z, Peng M, Liu C, Lin Z.
europepmc   +1 more source

Healthcare Information Management and Accreditation in Europe. [PDF]

Healthcare (Basel)
Ilinca R, Iosif L, Luțescu DA, Trică MV, Ganea I, Spînu TC, Țâncu AC.   +6 more
europepmc   +1 more source

Realizing Landau levels with open equifrequency contours around band singularities. [PDF]

Nat Commun
Lu C, You O, Zheng Y, Ma S, Yang Q, Chan HC, Wang Z, Ma W, Liu YC, Zhang S.   +9 more
europepmc   +1 more source