Results 131 to 140 of about 3,602,084 (334)
Laboratory investigations on the quality of leak tests and visual inspections of wastewater connection pipes carried out by specialist contractors [PDF]
, 2021 S. Ulutaş, Marc Wichern, Bert Bosseler
openalex +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Studies of highway skew slab-bridges with curbs. A report of an investigation conducted by the Engineering Experiment Station, University of Illinois, [PDF]
On t.p. of v. 2: A report of an investigation conducted by the Engineering Experiment Station, University of Illinois, in cooperation with the Bureau of Public Roads, U. S. Dept. of Commerce and the Division of Highways, State of Illinois.Bibliographical
Allen, John Winfield +1 more
core
Investigating the Site of Newton's Laboratory in Trinity College, Cambridge [PDF]
, 2005 It is not generally known that over the course of some thirty years, Isaac Newton carried out around four hundred chemical experiments in a private laboratory located in the walled garden immediately below his rooms in Trinity College, Cambridge.
Spargo, PE
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Acute flaccid paralysis with anterior myelitis - California, June 2012-June 2014. [PDF]
, 2014 In August 2012, the California Department of Public Health (CDPH) was contacted by a San Francisco Bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (AFP) associated with anterior ...
Ayscue, Patrick +17 more
core +1 more source
Ecotoxicology and Environmental SafetyTris(2-chloroethyl) phosphate (TCEP) and tris(2-chloro-1-methylethyl) phosphate (TCPP) are increasingly co-detected in various aquatic environments, yet their combined toxicity remains poorly understood.
Xin-Dan Cao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source