Results 161 to 170 of about 3,602,084 (334)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Laboratory Investigation of thrombophilia

Journal of Medical Biochemistry, 2014
Laboratory investigation of thrombophilia is aimed at detecting the well-established hereditary and acquired causes of venous thromboembolism, including activated protein C resistance/factor V Leiden mutation, prothrombin G20210A mutation, deficiencies of the physiological anticoagulants antithrombin, protein C and protein S, the presence of ...
openaire   +4 more sources

Laboratory and Clinical Investigation of Lysis Centrifugation Blood Culture Method for Fungemia

, 1991
Akira Yasuoka, Shigeru Kohno, Shigefumi Maesaki, Hiroshi Yamada, Mitsuo Kaku, Takashige Miyazaki, Hironobu Koga, Kohei Hara   +7 more
openalex   +2 more sources

Diagnosis, Manifestations, Laboratory Investigations, and Prognosis in Pediatric and Adult Cushing’s Disease in a Large Center in China

, 2021
Xueqing Zheng, Wang He, Wentai Zhang, Shanshan Feng, Yifan Liu, Shuo Li, Xinjie Bao, Lin Lü, Huijuan Zhu, Ming Feng, Renzhi Wang   +10 more
openalex   +1 more source

Laboratory Investigation of Renoxification from the Photolysis of Inorganic Particulate Nitrate [PDF]

, 2021
Qianwen Shi, Ye Tao, Jordan Krechmer, Colette L. Heald, J. G. Murphy, Jesse H. Kroll, Qing Ye   +6 more
openalex   +1 more source

Hereditary hemochromatosis beyond hyperferritinemia: Clinical and laboratory investigation of the patient's profile submitted to phlebotomy in two reference centers in southern Brazil. [PDF]

Genet Mol Biol, 2023
Kersting N, Fontana JC, Athayde FP, Carlotto FM, Machado BA, Araújo CDSR, Sekine L, Onsten TGH, Leistner-Segal S.   +8 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Loss Aversion and Intertemporal Choice: A Laboratory Investigation [PDF]

We present results from a laboratory study of loss aversion in the context of intertemporal choice. We investigate whether the provision of (windfall) endowments results in different elicited discount rates relative to subjects who earn income or earn ...
Morrison, William G., Oxoby, Robert J.
core  

Laboratory Investigation of Tomography-Controlled Continuous Steel Casting. [PDF]

Sensors (Basel), 2022
Glavinić I, Muttakin I, Abouelazayem S, Blishchik A, Stefani F, Eckert S, Soleimani M, Saidani I, Hlava J, Kenjereš S, Wondrak T.   +10 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source