Results 121 to 130 of about 3,368,001 (282)
LAPR: An experimental aircraft pushbroom scanner [PDF]
A three band Linear Array Pushbroom Radiometer (LAPR) was built and flown on an experimental basis by NASA at the Goddard Space Flight Center. The functional characteristics of the instrument and the methods used to preprocess the data, including ...
Heugel, F., Irons, J. I., Wharton, S. W.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Fabrication and evaluation of advanced titanium and composite structural panels [PDF]
Advanced manufacturing methods for titanium and composite material structures are being developed and evaluated. The focus for the manufacturing effort is the fabrication of full-scale structural panels which replace an existing shear panel on the upper ...
Bales, T. T. +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Review of the AGARD S and M panel evaluation program of the NASA-Lewis SRP approach to high-temperature LCF life prediction [PDF]
Twenty laboratories in six countries participated in testing their own materials of interest under their own laboratory conditions. In this way the results obtained provided validation of the Strainrange Partitioning (SRP) method for a wide range of ...
Hirschberg, M. H.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Laboratory testing of candidate robotic applications for space [PDF]
Robots have potential for increasing the value of man's presence in space. Some categories with potential benefit are: (1) performing extravehicular tasks like satellite and station servicing, (2) supporting the science mission of the station by ...
Purves, R. B.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Comparison of conventional semi automated methods with advanced and semi-automated laboratory techniques: New era in clinical diagnostics [PDF]
Al Ameen Journal of Medical SciencesAim: The Advanced diagnostic studies often employ sophisticated technology and techniques to provide detailed information about the patient’s health, which might not be obtained through conventional diagnostic methods.
Nandini Takkalaki +3 more
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