Results 171 to 180 of about 62,770 (310)

Bony labyrinth morphology reveals deep population history and isolation among Homo sapiens in prehistoric northeastern Africa (44-3 ka). [PDF]

Nat Commun
Martin N, Velemínský P, Urciuoli A, Varadzinová L, Honegger M, Ambrose SH, Antoine D, Brandt SA, Brůžek J, Cauliez J, Duday H, Grine F, Brukner Havelková P, Irish JD, Jesse F, Maréchal L, Maureille B, Ribot I, Rmoutilova R, Rougier H, Santos F, Thibeault A, Usai D, Vanderesse N, Varadzin L, Whiting RJ, Crevecoeur I.   +26 more
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Placental defects revealed by modelling Prader-Willi syndrome in mice. [PDF]

Dis Model Mech
Webberley AE, Boque-Sastre R, Bailey L, Charles C, Jones RA, Bunton-Stasyshyn R, Stewart ME, Wells SE, Chatelet DS, Robinson SK, Higgs MJ, John RM, Isles AR.   +12 more
europepmc   +1 more source

Chronic Labyrinthitis [PDF]

Proceedings of the Royal Society of Medicine, 1938
openaire   +2 more sources

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Extensive Cochlear Otosclerosis: CT-MRI Correlation and the Diagnostic Value of Contrast Enhancement. [PDF]

Diagnostics (Basel)
Tumeļkāns R, Eraslan C, Balodis A.
europepmc   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX). [PDF]

Toxicol Pathol
Foley JF, Picut CA, Chappell VA, Miller CN, Fenton SE, Blake BE.   +5 more
europepmc   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

A Lightweight and Transparent Composite-Perforated Janus Acoustic Metamaterial: Multi-Band Sound Absorption Realized via Asymmetric Integrated Design. [PDF]

Materials (Basel)
Liu X, Zhang G, Zhao J, Zhang R, Hu P.
europepmc   +1 more source