Results 161 to 170 of about 28,128 (299)

Nobiletin Ameliorates Aβ1–42‐Induced Cognitive Disorder and Mitochondrial Dysfunction via Targeting the Key Circadian Regulator Bmal1

Food Safety and Health, EarlyView.
Nobiletin (NOB) ameliorates Aβ‐induced Alzheimer’s pathology by restoring circadian rhythm via Bmal1. NOB rescues cognitive deficits, synaptic damage, and mitochondrial dysfunction in mice and neurons by enhancing Bmal1/Clock oscillations and downstream mitochondrial integrity, positioning circadian regulation as a therapeutic target for Alzheimer's ...
Huajing Gao, Qinglin Qu, Ning Wang, Xue Gao, Peihua Li, Yanquan Mou, Xiangrui Kong, Yannan Chen, Dapeng Li, Xintong Tan   +9 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage

Glia, EarlyView.
NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nbce1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in astrocytes, is ...
Okan Capuk, Elise Berthold, Kathiravan Kaliyappan, Mansi Avunoori, Rajesh Muduganti, Sanjana Krishna, Shamseldin Metwally, Mary McFarland, Shanshan Song, Victoria Fiesler, Sydney Fischer, Lesley M. Foley, T. Kevin Hitchens, Susannah Waxman, Ian A. Sigal, Shefeeq M. Theparambil, Gulnaz Begum   +16 more
wiley   +1 more source

Amphibians and Reptiles of Ethiopia—Biogeography, Conservation Priority Areas, and Potentials for “One Plan Approach” Conservation Measures 埃塞俄比亚的两栖爬行动物——生物地理学、保育优先区及“一体化方案”保育措施的潜力

Integrative Conservation, EarlyView.
In this study, we analyze the conservation status of Ethiopia's amphibian and reptile diversity in terms of coverage with protected areas and global representation in conservation breeding facilities. We identify conservation gaps and suggest priorities for improvement.
Kolja Sperling, Helen Isselhard, Thomas Ziegler, Dennis Rödder   +3 more
wiley   +1 more source

Forensic Psychiatric Evaluations of Juvenile Sexual Offenses and Criminal Responsibility Assessments

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescent sexual offending is a complex and multifaceted issue; however, existing research is predominantly derived from Western contexts, leading to gaps in understanding these behaviors in underrepresented regions. Criminal characteristics, psychiatric diagnoses, and cognitive factors, which are recognized to affect offending ...
Ilker Tasdemir (Taşdemir), Muhammed Emin Boylu, Mehmet Dogan (Doğan), Ahmet Safa Gurhan (Gürhan)   +3 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Sex differences in placental structure and gene expression in ICR mice during embryonic development. [PDF]

Sci Rep
Man X, Usui N, Doi M, Shimada S.
europepmc   +1 more source

Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice

Journal of Biophotonics, EarlyView.
Photobiomodulation (808 nm laser, optimized at 80 Hz, 30% duty cycle) significantly enhances mitochondrial function, reduces β‐amyloid deposition, and attenuates microglial activation in a 5XFAD Alzheimer's mouse model. Delayed luminescence serves as a novel bioenergetic marker, linking improved mitochondrial efficiency to cognitive and ...
Hong Bae Kim, Chang Kyu Sung
wiley   +1 more source

Immunological mechanisms in Meniere's disease. [PDF]

Front Immunol
Yuan VG, Xia A, Santa Maria PL.
europepmc   +1 more source

Sodium zirconium cyclosilicate, hyperkalaemia, and spironolactone optimization in heart failure with reduced ejection fraction: The REALIZE‐K open‐label run‐in phase

European Journal of Heart Failure, EarlyView.
Mark C. Petrie, David Z.I. Cherney, Akshay S. Desai, Jeffrey M. Testani, Subodh Verma, Khaja Chinnakondepalli, David Dolling, Shachi Patel, Magnus Dahl, James M. Eudicone, Lovisa Friberg, Mario Ouwens, Murillo O. Antunes, Kim A. Connelly, Vagner Madrini Jr, Luca Kuthi, Anuradha Lala, Miguel Lorenzo, Patrícia O. Guimarães, Marta Cobo Marcos, Béla Merkely, David Gonzales‐Calle, Julio Nuñez Villota, Iain Squire, Jan Václavík, Jerzy Wranicz, Mikhail N. Kosiborod   +26 more
wiley   +1 more source