AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model
Sensory Neuroscience, EarlyView.Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou +6 more
wiley +1 more source
The synergistic ototoxicity of adalimumab combined with methotrexate in the treatment of ankylosing spondylitis. [PDF]
Front NeurolWei H, Xu C.
europepmc +1 more source
Small, EarlyView.We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee +13 more
wiley +1 more source
The use of the Labyrinth Scale in the differential diagnosis of children aged 2 to 4 with a history of psychological distress, autism and different language outcomes. [PDF]
CodasBenfica TR +4 more
europepmc +1 more source
Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease
VIEW, EarlyView.This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin +5 more
wiley +1 more source
Comorbidity Patterns Between Hearing Loss and Symptomatic Dizziness in Middle‐Aged and Older Adults
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective To explore the comorbidity patterns between hearing loss and symptomatic dizziness (HL‐SD) in middle‐aged and older adults. Methods This cross‐sectional study used data from the 1999 to 2004 National Health and Nutrition Examination Survey (NHANES). After excluding incomplete data, 2961 participants aged 40–69 were analyzed. Logistic
Chun‐Yan Liu +6 more
wiley +1 more source
Tim1 Deficiency Mediates Gestational Hyperglycemia-Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction. [PDF]
Adv Sci (Weinh)She J +14 more
europepmc +1 more source
Neurologic evaluation of the ear
, 2004 The ear is a highly complex sensory organ responsible for the sense of hearing and for vestibular control of posture and eye movements. Diseases of the inner ear are common in dogs and cats and are often associated with neurologic dysfunction, including ...
DVM Laurie B Cook
core
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang +8 more
wiley +1 more source
Comparative performance of radiomics models based on 3D-FLAIR-CUBE and MPRAGE sequences gadolinium-induced labyrinth MRI protocols for predicting endolymphatic hydrops in Ménière's disease. [PDF]
Eur J Med ResZheng T +6 more
europepmc +1 more source