FinnGen data of 213 942 women was utilized in order to investigate the risk of cardiovascular disease in women with and without hypertensive disorders of pregnancy and with diverse genetic risks for cardiovascular disease and preeclampsia measured with polygenic risk scores.
Anna Kivioja+8 more
wiley +1 more source
Secondary endolymphatic hydrops: a clinical and literature overview. [PDF]
Venkatasamy A, Péporté ARJ.
europepmc +1 more source
Antimicrobial prescribing guidelines for horses in Australia
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt+18 more
wiley +1 more source
Otoneurological evaluation: definitions and scientific evidence of bedside assessment and complementary exams. Outcomes of the II Brazilian Forum of Otoneurology. [PDF]
Salmito MC+20 more
europepmc +1 more source
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro+14 more
wiley +1 more source
Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis. [PDF]
Shi W, Zhao Z, Zhai Y, Ye X, Xu F.
europepmc +1 more source
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa+2 more
wiley +1 more source
Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-<i>κ</i>B and p38 MAPK Signaling Pathways. [PDF]
Abdou HM+4 more
europepmc +1 more source
ABSTRACT Background To explore the prevalence of serious adverse events (SAEs) associated with retinal viral gene therapy and to examine trends influencing SAE occurrences in human gene therapy surgeries and pre‐clinical animal trials. Methods Literature review was performed to identify peer‐reviewed human and animal studies relevant to viral gene ...
Aubrey Berger+3 more
wiley +1 more source
Mechanisms and clinical significance of Tumarkin-like phenomenon during the final step of the Epley and Semont maneuver: insights from virtual simulation and literature review. [PDF]
Yang R, Yang X.
europepmc +1 more source