Results 221 to 230 of about 2,254,411 (313)

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Evolution of Gene Expression Across Functional Regions of the Mouse Placenta. [PDF]

Genome Biol Evol
Rodriguez-Caro F, Moore EC, Slanger A, Good JM.   +3 more
europepmc   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Chlorogenic Acid Alleviates Heat Stress-Induced Fetal Growth Restriction Through Gut-Placental Crosstalk by Reshaping Gut Microbiota and Mediating Keap1-Nrf2 Antioxidant Signaling. [PDF]

Antioxidants (Basel)
Wang C, Yan C, Wu S, He B, Yin Y, Xu C, Xiang Y, Zhang Y, Li J, Wu Y, Liu N, Qin Y.   +11 more
europepmc   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Comparative safety profiles of antibody-drug conjugates: a real-world analysis of monotherapy and combination regimens in solid tumors. [PDF]

Drug Deliv
Fan L, Yin Y, Zhuang W, He D, Wan R, Sun B, Bai H, Wang J.   +7 more
europepmc   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Rethinking Transthyretin Amyloidosis: Insights from Taiwan Illuminate a Global Challenge. [PDF]

Acta Cardiol Sin
Cheng YW, Wang CL.
europepmc   +1 more source

Depletion of Neurocan in the Prefrontal Cortex Impairs Temporal Order Recognition, Cognitive Flexibility and Perisomatic GABAergic Innervation. [PDF]

Cell Mol Neurobiol
Baidoe-Ansah D, Carceller H, Mirzapourdelavar H, Pérez-Rando M, Strackeljan L, Garcia-Vazquez B, Seidenbecher C, Kaushik R, Nacher J, Dityatev A.   +9 more
europepmc   +1 more source

Presenting the scientific discourse of biodiversity loss through drivers, solutions, and responsibilities

Conservation Biology, EarlyView.
Abstract Biodiversity loss is considered a major global issue, but at the same time, scientists interpret it differently, identifying varied drivers, solutions, and responsibilities in their published works. These interpretations shape the scientific narratives these scientists use to discuss biodiversity loss, which, in turn, affects policy through ...
Willem van Doorninck, Jelle Behagel
wiley   +1 more source