Bioactive Metabolite Production in the Genus Pyrenophora (Pleosporaceae, Pleosporales)
Toxins, 2022 The genus Pyrenophora includes two important cereal crop foliar pathogens and a large number of less well-known species, many of which are also grass pathogens.
Marco Masi +2 more
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Pharmaceutics, 2022 Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic
Dariusz Boczar, Katarzyna Michalska
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Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams [PDF]
Organic Letters, 2008 Macrocyclic bis-lactams have been synthesized by cyclodimerization of homoallylic amino esters employing a Zr(IV)-catalyzed ester-amide exchange protocol. Base-mediated transannular cyclizations have been identified to access both bicyclic [5-11] and tricyclic [5-8-5] frameworks in good yield and diastereoselectivity.
Chong, Han +5 more
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Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 [PDF]
, 2019 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as ...
Beglov, Dmitri +12 more
core +7 more sources
Synthesis of macrocyclic and medium-sized ring thiolactones via the ring expansion of lactams [PDF]
Organic & Biomolecular Chemistry, 2021 A method to ring expand lactams into macrocyclic thiolactones is reported that can be incorporated into successive ring expansion sequences.
Kleopas Y. Palate +4 more
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On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. [PDF]
, 2016 A Friedel-Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations
Curtin, Brice H +5 more
core +1 more source
Molecules, 2013 Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. A derivative having a 2-(dimethylamino)ethyl chain attached to the 5-position of the phenyl ring was recently identified as a selective G ...
Joseph E. Rice +7 more
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Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization [PDF]
, 2015 The success of a given macrocyclization reaction involves a very delicate balance of many different factors. First, a proper understanding of the basic thermodynamic and kinetic concepts underlying these processes is essential in defining the strategies ...
Burguete, M. Isabel +3 more
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A Highly Efficient Synthesis of Z-Macrocycles using Stereoretentive, Ruthenium-Based Metathesis Catalysts [PDF]
, 2017 A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported.
Ahmed, Tonia S., Grubbs, Robert H.
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Purification and structure elucidation of three naturally bioactive molecules from the new terrestrial Streptomyces sp. TN17 strain [PDF]
, 2011 Thirty litres of fermentation broth was extracted from the newly isolated Streptomyces sp. strain TN17 and various separation and purification steps led to the isolation of three pure bioactive compounds (1–3).
Coppel, Yannick +5 more
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