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An Overview of the Epidemiology of Multidrug Resistance and Bacterial Resistance Mechanisms: What Solutions Are Available? A Comprehensive Review. [PDF]

Microorganisms
Birlutiu V, Birlutiu RM.
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A convenient synthesis of macrocyclic lactams

Tetrahedron Letters, 1990
Abstract A facile method is described for the synthesis of macrocyclic lactams using dicarboxylic acids and diamines directly in the presence of diphenylphosphoryl azide.
Qian Ligang, Sun Zhong, Deffo Tamboue, Kristin Bowman Mertes   +3 more
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Radical Photocyclization Route for Macrocyclic Lactone Ring Expansion and Conversion to Macrocyclic Lactams and Ketones

The Journal of Organic Chemistry, 2013
A new method for the synthesis of macrocyclic lactones, lactams, and ketones, which utilizes photoinduced intramolecular radical cyclization reactions of substrates containing tethered carboxylic acids and α,β-unsaturated carbonyl moieties, has been uncovered.
Keisuke, Nishikawa, Yasuharu, Yoshimi, Kousuke, Maeda, Toshio, Morita, Ichiro, Takahashi, Tatsuya, Itou, Sho, Inagaki, Minoru, Hatanaka   +7 more
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Access to macrocyclic lactams. Application to a new series: the dibenzotetralactams

Tetrahedron Letters, 1995
Abstract A facile route is described for the synthesis of macrocyclic dibenzotetralactams derived from 1,2-diaminobenzene based on a stepwise approach using diacid dichlorides or mixed pivalic dianhydrides for ring closure. This method is applicable for the preparation of a variety of receptors of various ring size, heteroatom substitution and ...
Nathalie Arnaud, Claude Picard, Louis Cazaux, Pierre Tisnès   +3 more
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ChemInform Abstract: A Convenient Synthesis of Macrocyclic Lactams.

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L. QIAN, Z. SUN, T. DEFFO, K. BOWMAN MERTES   +3 more
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Synthesis of new macrocyclic lactams, lactones, and thiolactones

Chemistry of Heterocyclic Compounds, 1996
A general method has been developed for the preparation of 14-remembered cyclic lactams, lactones, and thiolactones from heteroaromatic amino acids.
A. A. Yavolovskii, �. I. Ivanov, Yu. �. Ivanov   +2 more
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Meta-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors

Journal of Medicinal Chemistry, 1997
The design, synthesis, and biochemical profile of meta-substituted benzofused macrocyclic lactams are described. The meta-substituted benzofused macrocyclic lactams were designed to have a degree of flexibility allowing the amide bond to occupy two completely different conformations while maintaining sufficient rigidity to allow for strong interaction ...
G M, Ksander, R, de Jesus, A, Yuan, R D, Ghai, C, McMartin, R, Bohacek   +5 more
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Ortho-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors

Journal of Medicinal Chemistry, 1997
The design and preparation of ortho-substituted benzofused macrocyclic lactams are described. The benzofused macrocyclic lactams were designed as neutral endopeptidase 24.11 (NEP) inhibitors. Docking studies were carried out in a model of thermolysin (TLN) using the MACROMODEL and QXP modeling programs to select suitable ring sizes.
G M, Ksander, R, de Jesus, A, Yuan, R D, Ghai, A, Trapani, C, McMartin, R, Bohacek   +6 more
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ChemInform Abstract: A NEW SYNTHESIS OF AMIDES AND MACROCYCLIC LACTAMS

Chemischer Informationsdienst, 1979
AbstractCarbonsäuren (I) reagieren mit Brenzcatechin‐boran und ähnlichen Estern zu den aktivierten Estern (II), die mit Aminen (III) unter Eliminierung der Borinsäureester (V) glatt zu den Amiden (IV) führen.
D. B. COLLUM, S. C. CHEN, B. GANEM
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Fluorescence quantum yield of the two novel macrocyclic lactams

Russian Journal of Physical Chemistry A, 2014
Fluorescence quantum yield of two novel compounds—dibenzo[c,k]-1,2-dithia-6,9-diazacyclododecane-5,10-dione (1) and dibenzo[c,k]-1,2-dithia-6,9-diaza-7-methylcyclododecane-5,10-dione (2) was studied by Williams method using anthracene as a reference.
Saeedeh Sepehrikia, Donya Arefi, Alireza Shams   +2 more
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