Toward the Bioremediation of Nylon Waste Materials: Genome Mining Leads to the Identification of a Thermostable Laurolactamase From Thermopolyspora flexuosa. [PDF]
ChemSusChemTo enhance nylon waste remediation, genome mining was used to identify a thermostable laurolactam hydrolase from Thermopolyspora flexuosa with activity against an important cyclic nylon derivative. Substrate scope analysis and structural modeling revealed key features controlling enzyme‐substrate compatibility, providing a promising foundation for ...
Cleveland ME +3 more
europepmc +2 more sources
Metal Acetylides in Cycloaddition Reactions [PDF]
, 2017 This review highlights recent advances in the synthesis of (hetero)aromatic systems via cycloaddition reactions of alkynylmetals with dienes and dipoles.
Comas-Barceló, J., Harrity, J.P.A.
core +1 more source
Direct polymerization of levulinic acid via Ugi multicomponent reactiont [PDF]
, 2016 A robust, direct and efficient approach has been developed for the utilization of levulinic acid (LevA) as a building block in the synthesis of polyamides.
Alonso +38 more
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Application of an Acyl-CoA Ligase from Streptomyces aizunensis for Lactam Biosynthesis [PDF]
, 2017 ε-Caprolactam and δ-valerolactam are important commodity chemicals used in the manufacture of nylons, with millions of tons produced annually. Biological production of these highly valued chemicals has been limited due to a lack of enzymes that cyclize ω-
Baidoo, Edward E. +5 more
core +3 more sources
Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.This work demonstrates the nontrivial reactivity of pyridine incorporated into a porphyrin framework. The most significant achievement is the contraction of the six‐membered ring to a pyrrole ring, which is a phenomenon of great interest to researchers in this field.
Paulina Krzyszowska +5 more
wiley +2 more sources
Total Synthesis of (+)-Madangamine D [PDF]
, 2016 Madangamines are a group of bioactive marine sponge alkaloids, embodying an unprecedented diazapentacyclic skeletal type. The enantioselective total synthesis of madangamine D has been accomplished, and represents the first total synthesis of an alkaloid
Amat Tusón, Mercedes +4 more
core +1 more source
Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs [PDF]
, 2017 Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose–response variability and the risks of bleeding.
Banner D. W. +9 more
core +2 more sources
Synthesis of macrocyclic lactam/lactone derivatives having antimicrobial activity [PDF]
Pure and Applied Chemistry, 1994 Abstract
Paul Helquist +12 more
openaire +1 more source
Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry [PDF]
, 2010 International audienceThe search for proteasome inhibitors began fifteen years ago. These inhibitors proved to be powerful tools for investigating many important cellular processes regulated by the ubiquitinproteasome pathway.
Génin, Emilie +2 more
core +3 more sources
Synthesis of fluvirucins and their aglycons, the fluvirucinins [PDF]
, 2016 Fluvirucins are bioactive macrolactam glycosides isolated from actinomycetes. This review gives an overview of this family of natural products, covering isolation, biological activities, biosynthesis, and total synthesis. The synthesis of fluvirucins and
Amat Tusón, Mercedes +3 more
core +1 more source