Remodelling of the natural product fumagillol employing a reaction discovery approach [PDF]
, 2011 In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points
Balthaser, Bradley R. +4 more
core +1 more source
Targeting antibiotic resistance [PDF]
, 2016 Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health.
Chellat, Mathieu F. +2 more
core +1 more source
Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
Organic Letters, 2011 A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-
Oh, Dong-Chan +3 more
openaire +3 more sources
Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]
, 2019 A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core +4 more sources
Intraorganellar acidification by V-ATPases: a target in cellproliferation and cancer therapy [PDF]
, 2010 V-ATPases are multicomponent proton pumps involved in the acidification of singlemembrane intracellular compartments such as endosomes and lysosomes.
Hernández López, Agustín +4 more
core +1 more source
Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides
Journal of Peptide Science, Volume 32, Issue 3, March 2026.As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama +2 more
wiley +1 more source
Borate esters: Simple catalysts for the sustainable synthesis of complex amides [PDF]
, 2017 Chemical reactions for the formation of amide bonds are among the most commonly used transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for amidation using a simple borate ester catalyst is reported.
Boulton, LT, Sabatini, MT, Sheppard, TD
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Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Peripheral Metal Complexes: Chlorophyll “Isomers” with Magnesium Bound to the Ring E ß-Keto Ester System [PDF]
, 1978 Peripheral magnesium complexes of methyl pheophorbides a and b, bacteriomethyl pheophorbide a, bacteriopheophytin a, and protopheophytin a have been prepared and characterized by UV-vis, IR, ‘H NMR, and luminescence spectroscopy.
Katz, J. J., Scheer, Hugo
core
Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials [PDF]
, 2018 This is a post-peer-review, pre-copyedit version of an article published in Applied microbiology and biotechnology The final authenticated version is available online at: http://dx.doi.org/10.1007/s00253-018-8776-0Drug resistance occurrence is a global ...
Bassegoda Puigdomenech, Arnau +3 more
core +2 more sources