Results 41 to 50 of about 3,980 (188)

Exploring the Substitution of the C21‐OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates

ChemBioChem, Volume 27, Issue 1, January 2026.
Via in silico docking of pyrichalasin H on G‐ and F‐actin, the C21‐OAc moiety is identified as a modifiable site tolerated for actin binding. Fluorescent [11]cytochalasan probes from pyrichalasin H and epoxycytochalasin C are obtained by selective C21‐OAc hydrolysis and acylation.
Mervic D. Kagho, Katharina Schmidt, Aishi Chakrabarti, Marius Karger, Christopher Lambert, Maurice Hauser, Russell J. Cox, Klemens Rottner, Marc Stadler, Theresia E. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

Benzothiazole durch C-C-Spaltung von alpha-[(2-Nitrophenyl)thio]ketonen [PDF]

, 1984
Einwirkung von Ammoniak bzw. Natronlauge auf die -[(2-Nitrophenyl)thio]ketone 4, 11a-c und 16 führt unter CC-Spaltung zu den Benzothiazol-N-oxid-Derivaten 8, 12ac und 17; aus dem 3-[(2-Nitrophenyl)thio]-4-piperidon-Derivat 22 entsteht der 2 ...
Babichev, Birkofer, Eiden, Gordon, Hoffmann, Hofmann, House, Kuehne, Linke, Schröder, Takahashi   +10 more
core   +1 more source

Rigid and concave, 2,4-cis-substituted azetidine derivatives: A platform for asymmetric catalysis. [PDF]

, 2018
A series of single enantiomer, 2,4-cis-disubstituted amino azetidines were synthesised and used as ligands for copper-catalysed Henry reactions of aldehydes with nitromethane. Optimisation of ligand substituents and the reaction conditions was conducted.
Feula, A, Fossey, JS, Leach, AG, Male, L, Yoshizawa, A   +4 more
core   +5 more sources

Packaging, Labeling, and Physical Characteristics and Sales Volume Assessment of Veterinary Antimicrobials in a Resource‐Limited Setting: Evidence From Hawassa Town, Ethiopia

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Background Antibiotics and anthelmintics are widely used in veterinary medicine to prevent, control, and treat infectious diseases. However, in resource‐limited settings, the widespread circulation of poor‐quality medicines and their inappropriate use have become major obstacles to delivering effective animal healthcare.
Lelisa Ache Yohannes, Yesuneh Tefera Mekasha, Melese Tilahun, Mikael Abreham, Gemmechu Hasen, Sileshi Belew, Lipi Buch   +6 more
wiley   +1 more source

Diamine ligands in copper-catalyzed reactions [PDF]

, 2010
The utility of copper-mediated cross-coupling reactions has been significantly increased by the development of mild reaction conditions and the ability to employ catalytic amounts of copper.
Buchwald, Stephen Leffler, Surry, David S.   +1 more
core   +2 more sources

Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic.

The Journal of Antibiotics, 1993
A new antitumor antibiotic vicenistatin was isolated from the culture broth of Streptomyces sp. HC34. The structure of vicenistatin was elucidated by NMR spectral analysis. Vicenistatin exhibited antitumor activity against human colon carcinoma Co-3 in the xenograft model.
K, Shindo, M, Kamishohara, A, Odagawa, M, Matsuoka, H, Kawai   +4 more
openaire   +3 more sources

Dissecting HOCl Action in Chronic Wound Biofilms: Proteomic Insights From a Host‐Relevant Model of Pseudomonas aeruginosa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Impact statement: We tested a gel containing a pure, stable form of hypochlorous acid (HOCl) against P. aeruginosa. To ensure our results reflect the true effects of HOCl we used a host‐relevant biofilm model. The HOCl gel disrupted bacterial metabolism, impacted proteins associated with virulence, and changed the abundance antibiotic resistance ...
Lori I. Robins, Philip Gafken, Chenwei Lin, Lisa Jones, Sarah E. Hooper   +4 more
wiley   +1 more source

Postsynthetic Modifications of Amide‐Enaminone‐Based [2]Rotaxanes for the Stereocontrolled Synthesis of Functionalized β‐Lactams

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Novel amido‐enaminone threads efficiently template the formation of hydrogen‐bonded [2]rotaxanes and enable diverse postsynthetic modifications. Benzyl groups promote diastereoselective cyclizations to interlocked lactams while the enaminone motif allows stopper exchange while preserving the mechanical bond.
Syed S. Razi, Isabel M. Perez‐Artigao, Mateo Alajarin, Alberto Martinez‐Cuezva, Jose Berna   +4 more
wiley   +1 more source

Analytical methodologies for the determination of pharmaceuticals and personal care products (PPCPs) in sewage sludge: A critical review [PDF]

, 2019
Producción CientíficaSeveral analytical approaches have been developed for the determination of emerging pollutants (EPs), including pharmaceuticals and personal care products (PPCPs) in environmental matrices. This paper reviews the sample preparation
Barrado Esteban, Enrique, López Serna, Rebeca, Pérez Elvira, Sara Isabel, Pérez Lemus, Nereida   +3 more
core   +2 more sources

Mixed Sugar—Nylon 14‐, 28‐ and 42‐Membered Ring Macrocyclic Lactams.

ChemInform, 2004
Abstract Hydrogenation of linear ω-azido-pentafluorophenyl esters from mixed oligomers of 6-amino-6-deoxy- d -galactonic acid (or 6-amino-6-deoxy- d -mannonic acid) and 6-aminohexanoic acid gives cyclic peptides containing 14-, 28- and 42-membered ring lactams.
Mayes, B, Cowley, A, Ansell, C, Fleet, G
openaire   +2 more sources