Results 51 to 60 of about 3,980 (188)

A General Synthesis Approach to Double‐Guanidinium Stapled Peptides and Foldamers

Chemistry – A European Journal, Volume 31, Issue 62, November 6, 2025.
Our previous guanidinium stapling strategy has been extended to the generation of bis‐guanidinium stapled peptides and foldamers. This rapid and efficient approach, developed on solid‐support, allows for easy modulation of the ring size and the nature of the linker to reach high affinity hDM2 binders.
Maxime Neuville, Marta Martin Bornez, Mathieu Bourgeais, Hugues Samueli, Laura Mauran, Sébastien R. Goudreau, Abdel‐Majid Khatib, Gilles Guichard, Morgane Pasco   +8 more
wiley   +1 more source

Diazine Endo‐Functionalized Tetraphenylethylene‐Based Cyclo[6]arenes for Molecular Recognition in Both Solution and Aggregate States

Aggregate, Volume 6, Issue 11, November 2025.
To overcome poor molecular recognition in dilute solutions of tetraphenylethylene‐embedded cyclo[6]arenes, three macrocycles with functionalized cavities featuring diazine groups as endo‐binding sites are synthesized. Their recognition affinity continuously improves with increasing hydrogen‐bond acceptance of diazine groups.
Nan Pan, Shuhong Liu, Weichen Tan, Linbin Yao, Jialin Xie, Kelong Zhu, Chunman Jia   +6 more
wiley   +1 more source

Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]

, 2016
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA, Croft, RA, Davis, OA, Doran, R, Morgan, KF   +4 more
core   +1 more source

Cremimycin, a Novel 19-Membered Macrocyclic Lactam Antibiotic, from Streptomyces sp.

The Journal of Antibiotics, 1998
A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH.
M, Igarashi, T, Tsuchida, N, Kinoshita, M, Kamijima, R, Sawa, T, Sawa, H, Naganawa, M, Hamada, T, Takeuchi, K, Yamazaki, M, Ishizuka   +10 more
openaire   +3 more sources

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Mass Spectrometry Reviews, Volume 44, Issue 6, Page 1013-1098, November/December 2025.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu, Annelaure Damont, Alain Perret, Olivier Firmesse, François Becher, Gwenaëlle Lavison‐Bompard, Amandine Hueber, Amina S. Woods, Ekaterina Darii, François Fenaille, Jean‐Claude Tabet   +10 more
wiley   +1 more source

Cage Amine Superbases: Synthesis and Studies of Nona(ethylene)Hexamine and Dodeka(ethylene)Octamine

Chemistry – A European Journal, Volume 31, Issue 58, October 16, 2025.
The strongest known cage‐amine bases, nona(ethylene)hexamine and dodeka(ethylene)octamine have been prepared and characterized using experimental and theoretical methods. Abstract The cage‐amine molecules nona(ethylene)hexamine and dodeka(ethylene)octamine, have been prepared by coupling 1,4,7‐triazacyclononane (tacn) or 1,4,7,10‐tetraazacyclododecane (
Kel Vin Tan, Dat Quoc Duong, Keith F. White, Brian J. Smith, Peter J. Barnard   +4 more
wiley   +1 more source

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura   +4 more
wiley   +1 more source

Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives [PDF]

, 2018
The growing awareness of the importance of chirality in conjunction with biological activity has led to an increasing demand for efficient methods for the industrial synthesis of enantiomerically pure compounds.
Ren, Qun, Ruth, Katinka, Thöny-Meyer, Linda, Zinn, Manfred   +3 more
core  

Engineered polyketides: Synergy between protein and host level engineering [PDF]

, 2017
Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical functionalities.
Bailey, Constance B., Barajas, Jesus F., Blake-Hedges, Jacquelyn M., Curran, Samuel, Keasling, Jay D.   +4 more
core   +2 more sources

Enantioselective synthesis of the ethyl analog of the marine alkaloid haliclorensin C [PDF]

, 2020
The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of the ethyl analog of the macrocyclic marine alkaloid haliclorensin C (compound 5) are reported.
Amat Tusón, Mercedes, Bosch Cartes, Joan, Guignard, Guillaume Michel Pablo, Llor Brunés, Núria, Pubill Sánchez, David   +4 more
core   +1 more source