Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini +3 more
wiley +1 more source
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides [PDF]
, 2016 This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms.
Hahn, Frank, Hemmerling, Franziska
core +3 more sources
Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence [PDF]
, 2018 A modular and diastereodivergent synthesis of tetrahydro-1H-pyrrolo[1,2d]diazepine-(2,5)-diones is presented. The tetrahydropyrrolodiazepinedione scaffold is obtained via a base-mediated three-step isomerization/tandem cyclization of amino acid-coupled ...
Brown, Lauren E. +3 more
core +1 more source
Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [PDF]
, 2012 Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic alkalinisation, increased acid
Hernández López, Agustín +3 more
core +1 more source
Der Nachweis eines Radikalketten-Mechanismus für die Knabe-Reaktion von 1,2-Dihydro-2-methylpapaverin [PDF]
, 1984 Die Knabe-Reaktion von 1,2-Dihydro-2-methylpapaverin (9) und die begleitende Eliminierungsreaktion wurden durch ihre gebrochene Reaktionsordnung und durch die Möglichkeit der Inhibition als Radikalkettenreaktionen erkannt, deren kettentragendes Radikal ...
Ahond +50 more
core +1 more source
Studies on viridenomycin, a novel 24-membered macrocyclic polyene lactam antibiotic.
The Journal of Antibiotics, 1992 A new antitumor antibiotic, designated AL081, was obtained from the culture filtrate of an actinomycete identified as Streptomyces gannmycicus, and found to be identical with viridenomycin by direct comparison. The structure of the antibiotic was determined by NMR spectral analysis including a variety of two-dimensional techniques to be a novel 24 ...
M, Nakagawa +4 more
openaire +3 more sources
In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease [PDF]
, 2017 Background: Current hepatitis C virus (HCV) therapies may cure ∼60% of infections. They are often contraindicated or poorly tolerated, underscoring the need for safer and more effective drugs.
Abid, Karim +13 more
core
Synthesis of 1,1-dioxobenzo[b]thiophene-2-ylmethyloxycarbonyl (Bsmoc) protected N-methyl amino acids by reduction of Bsmoc-5-oxazolidinones and their use in peptide synthesis [PDF]
, 2009 The synthesis of Bsmoc-N-Me amino acids is presented. The first step involves p-toluenesulfonic acid (TsOH) catalyzed condensation of a Bsmoc-amino acid with paraformaldehyde to furnish N-Bsmoc-5-oxazolidinone under MW irradn.
Gundala, Chennakrishnareddy, . +3 more
core
Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK [PDF]
, 2013 Alderton, W K +3 more
core +1 more source
Synthesis of Macrocyclic Lactams and Lactones Containing Sulfur and Nitrogen [PDF]
Macroheterocycles, 2012 Gumer Yu. Ishmuratov +5 more
openaire +1 more source