Results 131 to 140 of about 505,953 (316)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Lactate accumulation following isometric exercise training and its relationship with reduced resting blood pressure

, 2012
The purpose of this study was (a) to assess lactate accumulation during isometric exercise, and to quantify the shifts in accumulation following isometric training; and (b) to relate any training-induced changes in lactate accumulation to reductions in ...
Wiles, J., Coleman, Damian, Wiles, Jonathan D., Swaine, I., Devereux, G., Swaine, Ian, Devereux, Gavin R., Coleman, D.   +7 more
core   +1 more source

All-in-One Sustainable Thread Biosensor for Chemiluminescence Smartphone Detection of Lactate in Sweat

Biosensors
Thanks to their low-cost, portability, and sustainability, microfluidic thread-based analytical devices (μTADs) are emerging as an attractive analytical platform for wearable biosensing.
Emanuela Maiorano, Maria Maddalena Calabretta, Eugenio Lunedei, Elisa Michelini   +3 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Pre-hospital lactate testing in the recognition and management of sepsis and septic shock: A proof

, 2017
Sepsis is a common condition, with a high mortality rate. Patients with this condition are routinely encountered by ambulance clinicians, but recognition of septic shock can be challenging.
Robinson, M, Stanley, J, Kirby, K
core  

Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study

Frontiers in Medicine
BackgroundLate-onset sepsis (LOS) in very low birth weight (VLBW) infants confers substantial mortality risk. While lactate monitoring is standard, validated prognostic thresholds for mortality remain unestablished in this population.MethodsThis ...
Yu Lun, Yu Lun, Zuming Yang, Yanhong Li, Yanhong Li   +4 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Production of Butyrate from Lactate by a Newly Isolated Clostridium sp BPY5

, 2016
Lactate-utilizing bacteria play important roles in the production of Chinese strong-flavored liquor (CSFL). However, the identity of these bacteria and their lactate-utilizing properties are largely unknown.
Tang, QL, Tao, Y, Zhu, XY, Hu, XH, Jin, H, Xu, ZC, Li, XZ (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu 610041, Peoples R China., Li, XZ   +7 more
core   +1 more source

ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

Cell Reports Medicine
Summary: Although ACVR2A mutations are prevalent in non-viral hepatocellular carcinomas (HCCs), the underlying mechanism remains unelucidated. Our molecular investigation reveals that ACVR2A impairment induces hyperglycolysis through the inactivation of ...
Koya Yasukawa, Shu Shimada, Yoshimitsu Akiyama, Tomohiko Taniai, Yosuke Igarashi, Shu Tsukihara, Yoshiaki Tanji, Kentaro Umemura, Atsushi Kamachi, Atsushi Nara, Masahiro Yamane, Keiichi Akahoshi, Akira Shimizu, Yuji Soejima, Minoru Tanabe, Shinji Tanaka   +15 more
doaj   +1 more source