Results 231 to 240 of about 471,023 (292)

The predictive value of the lactate dehydrogenase-to-albumin ratio for mortality in patients with septic shock. [PDF]

Medicine (Baltimore)
Wu YY, Yao L.
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Association of serum lactate dehydrogenase levels with the severity of microvascular invasion in hepatocellular carcinoma: a retrospective cross-sectional study. [PDF]

J Gastrointest Oncol
Fan Y, Xiao G, Hu J.
europepmc   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source

β2-microglobulin is superior to lactate dehydrogenase and bulky disease for risk stratification in diffuse large B-cell lymphoma patients with IPI 1-2. [PDF]

Ann Hematol
Chang H, Hung YS, Kuo MC, Lin TL, Kao HW, Shih HJ, Su YJ, Ong YC, Chen NC.   +8 more
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Lactate Dehydrogenase to Albumin Ratio as a Predictor of Severe Community-Acquired Pneumonia in Patients Aged 60 years and Above: A Retrospective Cohort Study. [PDF]

Infect Drug Resist
Li C, Lian M, Ding L, Wang J.
europepmc   +1 more source

D- and L-lactate dehydrogenase reactions increase pH to lactate production and decrease pH to pyruvate production. [PDF]

Front Mol Biosci
Robergs R, Nalos M, Kelbich P, Jizerová A, Mervartová I, Vostrý M, Štengl M, Babuška V.   +7 more
europepmc   +1 more source

Serum lactate dehydrogenase and vascular endothelial growth factor A level as a predictor of treatment response in locally advanced-stage World Health Organisation type 3 nasopharyngeal carcinoma. [PDF]

Contemp Oncol (Pozn)
Sulaksana MA, Punagi AQ, Pieters NAL, Kadriyan H.   +3 more
europepmc   +1 more source

Inhibition Profiling of <i>Rhodiola crenulata</i> on Lactate Dehydrogenase Isoenzymes. [PDF]

Molecules
Wei YX, Asgari M, Zhao QF, Zhang SS, Alifujiang Z, Zhang F, Chen XP, Feng CG.   +7 more
europepmc   +1 more source