Results 351 to 360 of about 785,757 (422)

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, EarlyView.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis. [PDF]

J Pers Med
Lungu N, Popescu DE, Manea AM, Jura AMC, Doandes FM, Popa ZL, Gorun F, Citu C, Gruber D, Ciurescu S, Boia M.   +10 more
europepmc   +1 more source

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, EarlyView.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Mediation effect of stroke recurrence in the association between post-stroke lactate dehydrogenase and functional disability. [PDF]

Front Aging Neurosci
He Q, Wang M, Zhu H, Xiao Y, Wen R, Liu X, Shi Y, Zhang L, Wang Y, Xu B.   +9 more
europepmc   +1 more source

Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension. [PDF]

J Transl Med
Wu D, Wang S, Wang F, Zhang Q, Zhang Z, Li X.   +5 more
europepmc   +1 more source

Comments on "The mRNA and Protein Levels of the Glycolytic Enzymes Lactate Dehydrogenase A (LDHA) and Phosphofructokinase Platelet (PFKP) Are Good Predictors of Survival Time, Recurrence, and Risk of Death in Cervical Cancer Patients". [PDF]

Cancer Med
Shahraki HR.
europepmc   +1 more source

Effect of Preoperative Serum Lactate Dehydrogenase-to-Albumin Ratio on the Survival of Oral Cancer: A Retrospective Study. [PDF]

J Inflamm Res
Wang X, Ji X.
europepmc   +1 more source

Diagnostic value of monocyte chemoattractant protein-1 (MCP-1) and lactate dehydrogenase (LDH) in malignant pleural effusion: A cross-sectional study. [PDF]

Lung India
Muhammad I, Putra NPP, Setyawan UA, Setijowati N.   +3 more
europepmc   +1 more source

Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis. [PDF]

J Headache Pain
Cheng HJ, Chen NF, Chen WF, Wu ZS, Sun YY, Teng WN, Su FW, Sung CS, Wen ZH.   +8 more
europepmc   +1 more source

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Role of Mitochondrial Membrane Potential and Lactate Dehydrogenase A in Apoptosis.

Anti-Cancer Agents in Medicinal Chemistry, 2021
Apoptosis is a programmed cell death that occurs due to the production of several catabolic enzymes. During this process, several morphological and biochemical changes occur in mitochondria, the main organelle in the cell that participates in apoptosis ...
S. Zaib, Aqsa Hayyat, N. Ali, A. Gul, M. Naveed, Imtiaz Khan   +5 more
semanticscholar   +1 more source