Results 41 to 50 of about 124,586 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

METHANE SUPPRESSION BY CALCIUM SOAPS OF STEARIC, OLEIC AND LINOLEIC ACID MIXTURES IN CATTLE [PDF]

, 1997
Summary Two types of calcium soaps of fatty acids (Ca-FA) were used; Ca-FA-I (C 18:0 17.0%, C18:1 65.0%) and Ca-FA-2 (CI8:0 20.0%, CI8:140.0%, C18:2 35.0%).
Nishida, Takehiro, Terada, F., Purnomoadi, Agung, Kurihara, M, Shibata, M.   +4 more
core   +1 more source

Genome-wide transcriptomic analysis of intestinal tissue to assess the impact of nutrition and a secondary nematode challenge in lactating rats [PDF]

, 2011
Gastrointestinal nematode infection is a major challenge to the health and welfare of mammals. Although mammals eventually acquire immunity to nematodes, this breaks down around parturition, which renders periparturient mammals susceptible to re ...
Pemberton, Alan D, John F. Huntley, Burgess, S. T. G., Burgess Stewart T. G., Leigh A. Jones, Jones, Leigh A, Jones, L. A., Alan D Pemberton, Houdijk, JGM; id_orcid, Stewart T. G. Burgess, Jos G. M. Houdijk, Burgess, Stewart T G, Pemberton, AD, Kyriazakis, Ilias, Jones, LA, Jones Leigh A., Pemberton Alan D., Spiridoula Athanasiadou, Kyriazakis, I, Jos G M Houdijk, Huntley John F., Burgess, STG, Stewart T G Burgess, Ilias Kyriazakis, Houdijk, Jos G M, Kyriazakis Ilias, Houdijk, J. G. M., Huntley, John F, John F Huntley, Houdijk Jos G. M., Kyriazakis, I., Athanasiadou, Spiridoula, Huntley, J. F., Leigh A Jones, Huntley, JF, Athanasiadou Spiridoula, Pemberton, A. D., Athanasiadou, S., Alan D. Pemberton, Athanasiadou, S; id_orcid   +39 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Ultrasound imaging of the lactating breast: methodology and application

International Breastfeeding Journal, 2009
Ultrasound imaging has been used extensively to detect abnormalities of the non-lactating breast. In contrast, the use of ultrasound for the investigation of pathology of the lactating breast is limited. Recent studies have re-examined the anatomy of the
Geddes Donna T
doaj   +1 more source

Dietary Intake and Nutritional Status of Javanese Women in Rice Producing Areas: a Comparison between Lactating and Non-lactating Women

Indonesian Journal of Human Nutrition, 2021
Maintaining optimal maternal nutrition is essential for the mother’s health and the child’s growth and development. Throughout the lactating period, maternal nutrition is significant due to the child’s high nutritional needs. Therefore, an increase
Ilmia Fahmi, Ratna C Purwestri, Judith Lauvai, Ziba Barati, Whelma Bell, Nia Novita Wirawan   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Kajian Fisiologis Penggunaan Bovine Somatotropin (bST) Pada Sapi Pra Afkir

Jurnal Agripet, 2009
Studies of physiological bovine somatotropin (bST) on post lactating dairy  ABSTRACT. To increase of milk production nationally with used in dairy cattle business can assist to increase milk production, eighteen post lactating dairy cows in the highland
Dzarnisa Dzarnisa, Cut Aida Fitri
doaj   +1 more source