Results 101 to 110 of about 50,814 (176)
Physico-chemical composition and antimicrobial protein content of early lactation donkey milk
<p>The influence of early lactation on chemical composition and the concentration of antimicrobial proteins of donkey&rsquo;s milk produced in Cyprus were investigated. Milk samples from 10 female donkeys in their first season of lactation were collected at 7, 15 and 30d postpartum.
Ioannou, Christina A. +3 more
openaire +4 more sources
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Changes in milk composition of domestic Balkan donkeys’ breed during lactation periods
Changes in the milk composition during early, middle and late stage of lactation period were monitored in 10 individual autochthonous donkeys of the Domestic Balkan breed. Animals were grazing ad libitum during early and middle lactation, while supplements (meadow hay, corn and corn stalks) were added during the late lactation period.
Jasmina Lazarevic +6 more
openaire +3 more sources
O‐GlcNAcylation Stimulation Modulates Na+/K+ ATPase and Improves Outcomes in Hemorrhagic Shock
Acute stimulation of O‐GlcNAcylation via NButGT injections in rats subjected to hemorrhagic shock improves hemodynamic parameters, reduces organ dysfunction, and restores ionic imbalance. These beneficial effects are notably mediated through modulation of the Na+/K+‐ATPase pump, highlighting O‐GlcNAcylation as a promising therapeutic target in ...
Thomas Dupas +23 more
wiley +1 more source
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad +5 more
wiley +1 more source
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz +8 more
wiley +1 more source
Therapeutics are administered to donkeys based on dosage and intervals recommended for horses because few drugs have donkey-specific indications. Although, mebendazole (MBZ) has been licensed for use in horses there are no data available regarding its ...
Gokbulut C +4 more
core
Phase‐separated Ptbp1 droplets form molecular complexes containing multiple proliferation‐associated molecules. Ptbp1 granules containing four RNA recognition motifs (RRMs) domains are present in the nuclei of mouse cardiomyocytes specifically during the proliferative stage.
Tai Sada +7 more
wiley +1 more source
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David +4 more
wiley +1 more source

