Results 181 to 190 of about 334,363 (343)

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Interfacing mechanistic and breeding scheme simulation to predict selection response on lactation efficiency in dairy cows under different nutritional environments. [PDF]

Genet Sel Evol
Bouquet A, Slagboom M, Thomasen JR, Kargo M, Friggens NC, Puillet L.   +5 more
europepmc   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

High-fidelity telesimulation to teach lactation skills to primary care residents, a cluster randomized educational trial. [PDF]

BMC Med Educ
Hoyt-Austin A, Sadovnikova A, Muñoz S, Donohue LT, Tancredi DJ, Kair LR.   +5 more
europepmc   +1 more source

Effect of non-structural carbohydrate dietary content on the productive performance of Sarda primiparous ewes [PDF]

, 2004
BOVERA, FULVIA, CALABRO', SERENA, CUTRIGNELLI, MONICA ISABELLA, INFASCELLI, FEDERICO, PICCOLO, GIOVANNI, PICCOLO, VINCENZO, TUDISCO, RAFFAELLA, ZICARELLI F   +7 more
core   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Longitudinal study of the udder microbiome using genome-centric metagenomics uncovers pathogen-driven adaptation and succession. [PDF]

NPJ Biofilms Microbiomes
Duarte VDS, Franklin FV, Krysmann A, Porcellato D.   +3 more
europepmc   +1 more source

Comportement alimentaire et utilisation digestive d'une ration de composition constante chez la vache laitière en fin de gestation et début de lactation [PDF]

, 1982
Michel Doreau, B. Rémond, Jeanne FLÉCHET, Renée LEFAIVRE, A. Ollier, Claire Sornet   +5 more
openalex   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Determinants of early lactation failure in mothers of moderately preterm neonates: a multilevel analysis of survey data. [PDF]

Front Nutr
Hong F, Song L, Chu X, Zhu Y, Wei Y, Wang J, Zou R, Ji J.   +7 more
europepmc   +1 more source