Results 181 to 190 of about 124,354 (268)

Milk Production Performance, Handling and Utilization Practices, and Compositional Analysis of Local Goats in Garda Marta District, Southern Ethiopia. [PDF]

Vet Med Int
Manta M, Birhanu S, Tadele Y.
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Sustaining Breastmilk Expression and Direct Feeding at Breast for Very Low Birth Infants: A Qualitative Exploration of Parental Perspectives. [PDF]

Matern Child Nutr
Noonan M, Fitzgibbon V, Keyes R, McCarthy J, Bradshaw C, Tighe SM, Atkinson S, Connell DO, Byrt H, Shanahan M, Desmond J, Lloyd B, Healy S, Philips RK.   +13 more
europepmc   +1 more source

Early-Life High-Fat-Diet Exposure Induced Pre-Puberty Obesity-Related MASLD via Autophagy-Mediated Ferroptosis in Male C57BL/6J Mice. [PDF]

Nutrients
Zhang Z, Wu Y, Wu X, Zhao Y, Liang C, Xu J, Nie Z, Liu S, Lv T, Wu M, Zhai L.   +10 more
europepmc   +1 more source

Effects of production, fertility, health, management and conformation scores on longevity in six Swiss dairy breeds. [PDF]

Vet Anim Sci
Bieber A, Hediger F, Pfeifer C, Schnyder U, Leiber F, Walkenhorst M.   +5 more
europepmc   +1 more source

Correction: Integrated methylome-transcriptome profiling reveals epigenetic regulation of immune activation pathways and CSN3-associated lactation repression in bovine subclinical mastitis. [PDF]

J Anim Sci Biotechnol
Dwivedi S, Kumar A, De UK, Chauhan A, Agrawal RK, Khanna S, Upadhyay A, Singh A, Devatwal PC, Dutt T.   +9 more
europepmc   +1 more source