Advanced Science, EarlyView.This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang +11 more
wiley +1 more source
Phenotypic and genetic analysis of milking temperament and its correlation with milk production traits in South African Holstein cattle. [PDF]
Trop Anim Health ProdSiwele TT +5 more
europepmc +1 more source
Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
Impact of Maternal Parity and Direct-Fed Microbial Supplementation on Reproductive Performance, Digestibility, and Milk Quality from Early Gestation to Lactation in Sows. [PDF]
Animals (Basel)Kongpanna P +3 more
europepmc +1 more source
Advanced Science, EarlyView.The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du +21 more
wiley +1 more source
Characterizing serotonin expression throughout bovine mammary gland developmental stages and its relationship with 17β-estradiol at puberty. [PDF]
PLoS OneField SL +3 more
europepmc +1 more source
SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway
Advanced Science, EarlyView.Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang +9 more
wiley +1 more source
Development and validation of a model for predicting the risks for delayed onset of lactogenesis stage II for Chinese pregnant women. [PDF]
Sci RepLi W, Kuang G, Chen Y, Yu P, Zhang M.
europepmc +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Clinical lactation studies. Acting on key recommendations over the last decade. [PDF]
NPJ Womens HealthRowland Yeo K +5 more
europepmc +1 more source