Results 101 to 110 of about 21,122 (246)

Variance and covariance components and genetic parameters for fat and protein yield of first-lactation Holstein cows using random regression models

Revista Colombiana de Ciencias Pecuarias, 2014
Background: the genetic parameters of the lactation curve in dairy cattle can be analyzed as longitudinal data using Random Regression Models (RRM). Objective: to estimate the (co) variance components and genetic parameters for fat (F) and protein (P ...
Oscar D Múnera Bedoya, Ana C Herrera Ríos, Luis G González Herrera, Andrés F Henao Velásquez, Mario Cerón Muñoz   +4 more
doaj  

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Comparasion of lactation curve models in sheep

, 2020
Cilj ovog rada bio je utvrditi najbolji odgovarajući model laktacijskih krivulja za količinu mlijeka, sadržaj proteina i masti za istarsku i pašku ovcu. Podaci su prikupljeni od Ministarstva poljoprivrede za 2016., 2017. i 2018. godinu. Koristili smo pet
Barković, Sara
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Is it possible to accurately estimate lactation curve parameters in extensive beef production systems?

, 2022
ObjectiveThe objective was to characterize the lactation curve applying 3 different models using multiparous grazing beef cows.Materials and MethodsMilk production data from 99 British crossbred multiparous cows grazing native pastures were analyzed ...
QUINTANS, G., IEWDIUKOW, M., LEMA, O.M., VELAZCO, J.I.   +3 more
core  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

A Bayesian estimation of the lactation curve of a dairy cow

, 1985
A recursive procedure for the estimation of the lactation curve of a dairy cow, which allows the inclusion of prior information on the curve and which takes account of the correlation between successive observations, is described.
E. A. Goodall, D. Sprevak
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows. [PDF]

J Anim Breed Genet, 2020
Atashi H, Salavati M, De Koster J, Ehrlich J, Crowe M, Opsomer G, GplusE consortium, Hostens M.   +7 more
europepmc   +1 more source