Results 131 to 140 of about 829,404 (286)
Advanced Science, EarlyView.Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang +5 more
wiley +1 more source
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Modelling lactation curve with explicit representation of perturbations
, 2018 International audienceAnimal husbandry aims at managing the environment of animals to enable them to express their production potential. However, ruminants are often confronted with perturbations that affect their performance.
Martin, Olivier +4 more
core +2 more sources
Conditioning Factors of Linearized Wood's Function Lactation Curve Shape Parameters, Milk Yield, Fat and Protein Content in Murciano-Granadina Primiparous Does. [PDF]
Animals (Basel), 2020 Delgado Bermejo JV +5 more
europepmc +1 more source
Lactation Curve Traits of Holstein Cows Raised at Polatli State Farm
, 2009 This study was done to determine lactation curves traits of Holstein cows raised at Polatli State Farm. Gamma curve parameters (Yt = at(b)e(-ct)) of Wood were used in determination of the types of lactation curve. In this study, values of parameters a, b,
Çilek, Süleyman +2 more
core +1 more source
BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu +16 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source