Results 201 to 210 of about 3,019,565 (364)

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Development of lactation and breast/chestfeeding adverse event terminology (LaBAET) through a Delphi consensus approach. [PDF]

Int Breastfeed J
Maksym KM, Kalita-Kurzyńska K, Spatz D, Boss M, Collado MC, Gonciarz-Dytman A, Han B, Khalil A, Kozakiewicz J, Kuchar E, Morze K, Powell R, Shenker N, Wątroba S, David AL, Wesołowska A.   +15 more
europepmc   +1 more source

Sleep Pharmacotherapy for Common Sleep Disorders in Pregnancy and Lactation [PDF]

, 2020
Mahadevappa Hunasikatti
openalex   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Psychopharmacological Decision Making in Bipolar Disorder During Pregnancy and Lactation: A Case-by-Case Approach to Using Current Evidence

, 2019
Elizabeth Albertini, Carrie L. Ernst, Rachel S. Tamaroff   +2 more
openalex   +2 more sources

Pharmacotherapy for depression and bipolar disorder during lactation: A framework to aid decision making

, 2020
Jennifer Sprague, Katherine L. Wisner, Debra L. Bogen   +2 more
openalex   +2 more sources

Case Study: Combined risk factors and digestive disorders in mid-lactation Holstein cows

, 2022
S.T. Quanz, K.E. Griswold, L.K. Mamedova, S.K. Kvidera, M.J. Brouk, R.S. Fry, B.J. Bradford   +6 more
openalex   +1 more source

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

Sweat Wearable Sensor Based on Confined Pt Nanoparticles in 2D Conductive Metal–Organic Frameworks for Continuous Glucose Monitoring

Advanced Science, EarlyView.
An integrated wearable system is developed for nonenzymatic sweat glucose monitoring at the point of care. The system couples a microfluidic patch based on Pt nanoparticles confined in phthalocyanine‐based conductive MOFs with a flexible wireless circuit.
Wei Huang, Yong Yang, Yun Xu, Fei Xiao, Lin Wang   +4 more
wiley   +1 more source