Results 221 to 230 of about 39,607 (289)

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Seroprevalence and Associated Risk Factors of Peste des Petits Ruminants Virus in Small Ruminants of Punjab, Pakistan. [PDF]

Transbound Emerg Dis
Alvi MA, Yan HB, Kharl RB, Ali A, Zeeshan M, Jia WZ, Ren S, Meng X, Zhu X, Ghafoor M, Saqib M, Li L, Dou Y.   +12 more
europepmc   +1 more source

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

Arthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H.W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring. [PDF]

J Neurochem
Schmitt LO, Faraco G, Stivanin TS, Gaspar JM.   +3 more
europepmc   +1 more source

First study into the temporal relationship between metabolic disorders and lameness events over the course of a lactation

, 2018
Axelle Mineur, C. Egger-Danner, Johann Sölkner, Sylvie Vanderick, Hedi Hammami, Nicolas Gengler   +5 more
openalex   +1 more source

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Nutrition in Perinatal Midwifery Care: A Narrative Review of RCTs, Current Practices, and Future Directions. [PDF]

Healthcare (Basel)
Kokkinari A, Dagla M, Gourounti K, Antoniou E, Tsinisizeli N, Tzamakos E, Iatrakis G.   +6 more
europepmc   +1 more source

Endocrine disorders in the programming model by exposure tobacco smoke in lactation

, 2013
Ana Carolina Gondim de Albuquerque Oliveira
openalex   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

A Bio-Economic Evaluation of Var, LnVar, and r-Auto Resilience Indicators in Czech Holstein Cattle. [PDF]

Animals (Basel)
Krupová Z, Kašná E, Zavadilová L, Krupa E.   +3 more
europepmc   +1 more source