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The Diagnostic Utility of Lactate Sensitivity in Panic Disorder
Archives of General Psychiatry, 1990Lactate infusion is the most extensively studied of the pharmacological challenge tests in panic disorder. We assessed the value of this test in the diagnosis and subtyping of panic in clinical and research settings. Analysis of lactate infusion studies to date suggests that patients with panic attacks are significantly more sensitive to lactate than ...
Deborah S. Cowley, George W. Arana
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Calcium and Bone Disorders During Pregnancy and Lactation
Endocrinology and Metabolism Clinics of North America, 2006Adaptations in mineral metabolism occur during pregnancy and lactation, and these adaptations uniquely affect the presentation, diagnosis, and management of disorders of calcium and bone metabolism. Maternal adaptations to pregnancy and lactation have evolved differently over time, such that dietary calcium absorption dominates in pregnancy, whereas ...
Ghada El-Hajj Fuleihan +1 more
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Imaging of pregnant and lactating patients with suspected adrenal disorders
Reviews in Endocrine and Metabolic Disorders, 2022A high level of clinical suspicion is essential in the diagnosis and management of a suspected adrenal mass during pregnancy and the peripartum period. Timely recognition is important in order to improve fetal and maternal outcomes. Imaging is often performed to confirm a suspected adrenal lesion; however, increasing usage of diagnostic imaging during ...
Molly E. Roseland +2 more
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Lactate: A New Target for Brain Disorders
NeuroscienceLactate in the brain is produced endogenously and exogenously. The primary functional cells that produce lactate in the brain are astrocytes. Astrocytes release lactate to act on neurons, thereby affecting neuronal function, through a process known as the astrocyte-neuron shuttle.
Shunfeng Liu, Shouhong Zhou
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Sodium lactate response as a model for panic disorders
Trends in Neurosciences, 1984An important advance in our understanding of panic disorder is the use of an infusion of sodium lactate as a biological stimulus of an attack, which should enable researchers to investigate such attacks under laboratory conditions.
Samuel G. Siris, Arthur Rifkin
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Panic disorder: Response to sodium lactate and treatment with antidepressants
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1985Effective drugs for mental disorders have been found by serendipitous findings not supported by knowledge of psychopharmacology. Drug are assigned labels, such as "antidepressant" without knowledge that such a label delimits the utility of such agents. Many double-blind controlled studies have shown that imipramine effectively ameliorates panic attacks
Samuel G. Siris, Arthur Rifkin
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Effect of Flumazenil in Lactate-Sensitive Patients With Panic Disorder
American Journal of Psychiatry, 1998Flumazenil is a benzodiazepine receptor antagonist that has been reported to provoke panic attacks in patients with panic disorder. This study was undertaken to compare the effects of flumazenil and sodium lactate, the most widely studied panic provocation agent.Ten patients with panic disorder were given infusions of saline, sodium lactate, and ...
Klaus Wiedemann +4 more
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Lactate sensitivity and cardiac cholinergic function in panic disorder
American Journal of Psychiatry, 1994Using spectral analysis of the continuous time series signal before and during lactate and placebo infusions, the authors studied heart rate variability in six patients with panic disorder and nine normal comparison subjects. The decrease in high-frequency (0.20-0.50 Hz) power and the increase in sympathovagal ratios (mid-frequency [0.07-0.15 Hz] to ...
Vikram K. Yeragani +4 more
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Lactate overproduction in platelets of subjects affected with myeloproliferative disorders
Scandinavian Journal of Haematology, 1985In platelets of patients affected with myeloproliferative disorders, glycolytic and glycogenolytic flux have been examined. Results of studies on glucose uptake, glycogen breakdown and lactate formation have been reported. No difference in glucose uptake between controls and patients was observed, but in patients a higher lactate formation was always ...
M. Maresca +3 more
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Screening and treatment of anxiety disorders in pregnant and lactating women
Women's Health Issues, 2002Untreated anxiety disorders during pregnancy and the postpartum period may pose significant risks to the unborn fetus and interfere with a mother's ability to properly care for her newborn child. As the symptoms of anxiety disorders are often similar to those found in pregnancy, careful screening for anxiety disorders in pregnant women is essential ...
Risa B. Weisberg, Julie A. Paquette
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