Results 61 to 70 of about 549,247 (252)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

PhD on Track og åpen publisering

Nordic Journal of Information Literacy in Higher Education, 2020
PhD on Track er en åpen, fritt tilgjengelig nettressurs beregnet på stipendiater og yngre forskere. I de to siste årene (2017-2018) er ressursen endret fra et dansk-norsk samarbeid til et samarbeid mellom flere norske institusjoner.
Hege Charlotte Faber, Torstein Låg
doaj   +1 more source

Lag Length Selection for Unit Root Tests in the Presence of Nonstationary Volatility [PDF]

A number of recently published papers have focused on the problem of testing for a unit root in the case where the driving shocks may be unconditionally heteroskedastic.
Stephan Smeekes, Peter C.B. Phillips, A.M. Robert Taylor, Giuseppe Cavaliere   +3 more
core   +2 more sources

Lag-response association specific to rainfall category 2(0 mm

, 2016
Lag-response association specific to rainfall category 2(0 ...
Pin Wang (300672), William B. Goggins (318360), Emily Y. Y. Chan (318362)   +2 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Nonlinear differential equations with deviating arguments and approximations via a Parker-Sochacki approach

Electronic Journal of Differential Equations, 2017
The Parker-Sochacki method has been successful in generating approximations for a wide variety of ODEs, and even PDEs of evolution type, by achieving an autonomous polynomial vector field and implementing the Picard iteration.
Vincenzo M. Isaia
doaj  

Ridge Estimators for Distributed Lag Models [PDF]

The paper explains how the Almon polynominal lag specification can be made stochastic in two different ways - one suggested by Shiller and another following the lines of Lindley and Smith.
G.S. Maddala
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

From the help desk: Polynomial distributed lag models [PDF]

Polynomial distributed lag models (PDLs) are finite-order distributed lag models with the impulse-response function constrained to lie on a polynomial of known degree.
Allen McDowell
core