Results 1 to 10 of about 19,885,242 (297)

The in vivo measurement of replication fork velocity and pausing by lag-time analysis. [PDF]

Nat Commun, 2023
Lag-time analysis was developed to measure in vivo replisome dynamics. Observed dynamics are both locus and cell-cycle dependent: Pauses of seconds are observed at wild-type ribosomal DNA loci, as well as temporal fork velocity oscillations. An important
Huang D, Johnson AE, Sim BS, Lo TW, Merrikh H, Wiggins PA.   +5 more
europepmc   +2 more sources

Tradeoff between lag time and growth rate drives the plasmid acquisition cost. [PDF]

Nat Commun, 2023
Plasmid acquisition imposes a transient burden on bacterial hosts. Here, authors show this burden results in a tradeoff between growth and lag that dictates plasmid fate, favoring intermediate cost plasmids over both low and high cost counterparts ...
Ahmad M, Prensky H, Balestrieri J, ElNaggar S, Gomez-Simmonds A, Uhlemann AC, Traxler B, Singh A, Lopatkin AJ.   +8 more
europepmc   +2 more sources

COVID-19 mortality and exposure to airborne PM_2.5: A lag time correlation. [PDF]

Sci Total Environ, 2022
COVID-19 has escalated into one of the most serious crises in the 21st Century. Given the rapid spread of SARS-CoV-2 and its high mortality rate, here we investigate the impact and relationship of airborne PM2.5 to COVID-19 mortality.
Shao L, Cao Y, Jones T, Santosh M, Silva LFO, Ge S, da Boit K, Feng X, Zhang M, BéruBé K.   +9 more
europepmc   +2 more sources

String Method with Swarms-of-Trajectories, Mean Drifts, Lag Time, and Committor. [PDF]

J Phys Chem A, 2021
The kinetics of a dynamical system comprising two metastable states is formulated in terms of a finite-time propagator in phase space (position and velocity) adapted to the underdamped Langevin equation.
Roux B.
europepmc   +2 more sources

Lag time between state-level policy interventions and change points in COVID-19 outcomes in the United States. [PDF]

Patterns (N Y), 2021
Summary State-level policy interventions have been critical in managing the spread of the new coronavirus. Here, we study the lag time between policy interventions and change in COVID-19 outcome trajectory in the United States.
Dey T, Lee J, Chakraborty S, Chandra J, Bhaskar A, Zhang K, Bhaskar A, Dominici F.   +7 more
europepmc   +2 more sources

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries. [PDF]

Cancers (Basel), 2021
Simple Summary The authors aimed to determine the lag time between onset of symptoms and diagnosis of retinoblastoma in countries based on their national-income and analyse its effect on the outcomes. Based on analysis of 692 retinoblastoma patients from
Kaliki S, Ji X, Zou Y, Rashid R, Sultana S, Taju Sherief S, Cassoux N, Y Diaz Coronado R, Luis Garcia Leon J, López AMZ, Polyakov VG, Ushakova TL, Rani Roy S, Ahmad A, Al Harby L, Reddy MA, Sagoo MS, L Berry J, Kim J, Polski A, Astbury NJ, Bascaran C, Blum S, Bowman R, Burton MJ, Foster A, Gomel N, Keren-Froim N, Madgar S, W Stacey A, M Steinberg D, Mohamed A, Zondervan M, Fabian ID.   +33 more
europepmc   +2 more sources

Wide lag time distributions break a trade-off between reproduction and survival in bacteria. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance The biology of many microorganisms has been adapted to a feast-and-famine lifestyle. Thus, understanding population dynamics during transitions from starvation to resource abundance is important for fundamental and applied reasons.
Moreno-Gámez S, Kiviet DJ, Vulin C, Schlegel S, Schlegel K, van Doorn GS, Ackermann M.   +6 more
europepmc   +2 more sources

The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: a scoping review of systematic reviews and meta-analyses

medRxiv, 2022
Background: The COVID-19 pandemic has disrupted cancer care, raising concerns regarding the impact of wait time, or lag time, on clinical outcomes. We aimed to contextualize pandemic-related lag times by mapping pre-pandemic evidence from systematic ...
Tope P, Farah E, Ali R, El-Zein M, Miller WH, Franco EL.   +5 more
europepmc   +2 more sources

Case-Fatality Risk Estimates for COVID-19 Calculated by Using a Lag Time for Fatality. [PDF]

Emerg Infect Dis, 2020
We estimated the case-fatality risk for coronavirus disease cases in China (3.5%); China, excluding Hubei Province (0.8%); 82 countries, territories, and areas (4.2%); and on a cruise ship (0.6%). Lower estimates might be closest to the true value, but a
Wilson N, Kvalsvig A, Barnard LT, Baker MG.   +3 more
europepmc   +2 more sources

Lag time for diagnosis and treatment in 1120 retinoblastoma children: Analysis from InPOG-RB-19-01 [PDF]

Indian Journal of Ophthalmology
Setting: Increased lag time for diagnosis and treatment is a key determinant of adverse retinoblastoma (RB) outcomes. Analysis from INPHOG-RB-19-01, a prospective, multicentric study of newly diagnosed RB with regard to lag time and its correlation with ...
Sima Das, Rachna Meel, Amita Mahajan, Rolika Bansal, Vijay Anand Reddy, Subhav Prasad, Neiwete Lomi, Sameer Bakhshi, Seema Kashyap, Kasturi Bhattacharjee, Devjyoti Tripathy, Nishant Verma, Usha Singh, Parag K Shah, Mobashir Sarfraz Ali, Asim Ghosh, Aakar Singh, Santosh G Honavar   +17 more
doaj   +2 more sources