The in vivo measurement of replication fork velocity and pausing by lag-time analysis. [PDF]
Nat Commun, 2023 Lag-time analysis was developed to measure in vivo replisome dynamics. Observed dynamics are both locus and cell-cycle dependent: Pauses of seconds are observed at wild-type ribosomal DNA loci, as well as temporal fork velocity oscillations. An important
Huang D +5 more
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Tradeoff between lag time and growth rate drives the plasmid acquisition cost. [PDF]
Nat Commun, 2023 Plasmid acquisition imposes a transient burden on bacterial hosts. Here, authors show this burden results in a tradeoff between growth and lag that dictates plasmid fate, favoring intermediate cost plasmids over both low and high cost counterparts ...
Ahmad M +8 more
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String Method with Swarms-of-Trajectories, Mean Drifts, Lag Time, and Committor. [PDF]
J Phys Chem A, 2021 The kinetics of a dynamical system comprising two metastable states is formulated in terms of a finite-time propagator in phase space (position and velocity) adapted to the underdamped Langevin equation.
Roux B.
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Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries. [PDF]
Cancers (Basel), 2021 Simple Summary The authors aimed to determine the lag time between onset of symptoms and diagnosis of retinoblastoma in countries based on their national-income and analyse its effect on the outcomes. Based on analysis of 692 retinoblastoma patients from
Kaliki S +33 more
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Lag time, high-risk histopathological features, metastasis, and survival interrelation in retinoblastoma: a perspective from lower-middle income country [PDF]
International Journal of Ophthalmology, 2022 AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr ...
Purjanto Tepo Utomo +8 more
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Wide lag time distributions break a trade-off between reproduction and survival in bacteria. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance The biology of many microorganisms has been adapted to a feast-and-famine lifestyle. Thus, understanding population dynamics during transitions from starvation to resource abundance is important for fundamental and applied reasons.
Moreno-Gámez S +6 more
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Case-Fatality Risk Estimates for COVID-19 Calculated by Using a Lag Time for Fatality. [PDF]
Emerg Infect Dis, 2020 We estimated the case-fatality risk for coronavirus disease cases in China (3.5%); China, excluding Hubei Province (0.8%); 82 countries, territories, and areas (4.2%); and on a cruise ship (0.6%). Lower estimates might be closest to the true value, but a
Wilson N +3 more
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medRxiv, 2022 Background: The COVID-19 pandemic has disrupted cancer care, raising concerns regarding the impact of wait time, or lag time, on clinical outcomes. We aimed to contextualize pandemic-related lag times by mapping pre-pandemic evidence from systematic ...
Tope P +5 more
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Power-law tail in lag time distribution underlies bacterial persistence. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Persisters are antibiotic-tolerant cells that can evade antibiotic killing by maintaining long lag phase. They complicate antibiotic treatment, leading to treatment failure.
Şimşek E, Kim M.
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Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters. [PDF]
Nat Commun, 2018 Persisters are a subpopulation of bacteria that are not killed by antibiotics even though they lack genetic resistance. Here we provide evidence that persisters can manifest as small colony variants (SCVs) in clinical infections.
Vulin C +4 more
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