Results 91 to 100 of about 18,294,799 (361)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Properties of unique hard X-ray dips observed from GRS 1915+105 and IGR J17091-3624 and their implications

open access: yes, 2013
We report a comprehensive study on spectral and timing properties of hard X-ray dips uniquely observed in some so-called variability classes of the micro-quasars GRS 1915+105 and IGR J17091-3624.
Bhattacharyya, Sudip   +5 more
core   +2 more sources

The changing X-ray time lag in MCG-6-30-15 [PDF]

open access: yes, 2014
MCG-6-30-15 is one of the most observed Narrow Line Seyfert 1 galaxies in the X-ray band. In this paper we examine the X-ray time lags in this source using a total of 600 ks in observations (440 ks exposure) taken with the XMM-Newton telescope (300 ks in
Alston, W.   +8 more
core   +1 more source

Lag time determination in DEC measurements with PTR-MS [PDF]

open access: yesAtmospheric Measurement Techniques, 2010
The disjunct eddy covariance (DEC) method has emerged as a popular technique for micrometeorological flux measurements of volatile organic compounds (VOCs).
R. Taipale, T. M. Ruuskanen, J. Rinne
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

In vitro lipid peroxidation of LDL from postmenopausal cynomolgus macaques treated with female hormones

open access: yesJournal of Lipid Research, 1999
Premenopausal women and postmenopausal women given estrogen are protected from cardiovascular diseases compared with men. Previous studies investigated whether estrogen treatment protects low density lipoprotein (LDL) from in vitro oxidation as a ...
Dawn C. Schwenke   +2 more
doaj  

Modeling the impact of legacy nitrogen accumulated in agricultural soil-groundwater on water quality improvement

open access: yesEnvironmental Research Letters
Nitrogen (N) legacy effects are widely recognized as a primary obstacle to the improvements of water quality following mitigation efforts. The exploration of long-term nutrient trajectories for nitrogen model (ELEMeNT-N) has been applied to estimate ...
Jia Zhou   +10 more
doaj   +1 more source

Time lag and communication in changing unpopular norms. [PDF]

open access: yesPLoS ONE, 2015
Humans often coordinate their social lives through norms. When a large majority of people are dissatisfied with an existing norm, it seems obvious that they will change it. Often, however, this does not occur.
Klarita Gërxhani, Jeroen Bruggeman
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Reverberation Measurements of the Inner Radius of the Dust Torus in Nearby Seyfert 1 Galaxies

open access: yes, 2005
The most intense monitoring observations yet made in the optical (UBV) and near-infrared (JHK) wave bands were carried out for nearby Seyfert1 galaxies of NGC 5548, NGC 4051, NGC 3227, and NGC 7469.
Antonucci R.   +16 more
core   +2 more sources

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