Results 61 to 70 of about 12,144 (303)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
THE THEOLOGICAL DEBATE OVER HUMAN ENHANCEMENT: AN EMPIRICAL CASE STUDY OF A MEDIATING ORGANIZATION
Zygon, 2020 For most theologians, theology should ultimately be used by the laity and/or the public. However, the religion and science debate has not focused on the divide between theologians and the laity.
doaj +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Professor Father A.L. Szafrański Promotion of the Laity
, 2015 Ks. prof. dr hab. Adam Ludwik Szafrański był znany w środowisku jako promotor ludzi świeckich w Kościele. Dotyczyło to przede wszystkim, choć nie wyłącznie, ludzi świeckich studiujących teologię, co w okresie posoborowym było pewną nowością, ale też ...
Wojaczek, Krystian
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Laity in Biblical Perspective
, 1979 “The ‘new direction’ which a biblical perspective on the Christian laity requires of us today … will be realized only if the ‘nonclergy’ are willing to move up, if the ‘clergy’ are willing to move over, and if all God's people are willing to move out.”
Thomas W. Gillespie
core +1 more source
Hans Urs von Balthasar, un testigo ausente del concilio Vaticano II
Wrocławski Przegląd TeologicznyEl presente artículo muestra las ideas teológicas de Hans Urs von Balthasar sobre el Vaticano II. El teólogo suizo fue un atento espectador del concilio, incluso cuando no estuvo físicamente presente en el evento eclesial.
Pablo Blanco-Sarto
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source