Results 71 to 80 of about 3,944 (168)

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, Volume 9, Issue 9, Page 1782-1794, September 2026.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Identification of LAMA2 compound heterozygous variants: a case report

Translational Pediatrics
Laminin-α2 (LAMA2) chain-deficient muscular dystrophy (LAMA2-MD) is the most common congenital muscular dystrophy (CMD) in the world. Its main manifestations are muscle weakness and hypotonia that occur after birth or at early infancy.We reported a case of a 3-year-old and 6-month-old boy presented with delayed motor development, elevated creatine ...
Ying, Yingchao, Ye, Jia, Shen, Jue, Chen, Guojuan, Jiang, Kewen   +4 more
openaire   +2 more sources

TLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune Microenvironment

MedComm – Oncology, Volume 5, Issue 3, September 2026.
In tail‐vein and orthotopic osteosarcoma mouse models, 1V209‑Cho‑Lip, a TLR7 agonist liposome, effectively suppresses pulmonary metastasis and prolongs survival. Flow cytometry and single‑cell transcriptomics reveal that 1V209‑Cho‑Lip remodels both the pre‑metastatic and post‑metastatic immune microenvironments, alleviates myeloid‑mediated ...
Xinyue Zhang, Hao Zeng, Furong Qin, Yuquan Wei, Dandan Wan, Xiawei Wei   +5 more
wiley   +1 more source

Whole Exome Sequencing as a Diagnostic Tool for Unidentified Muscular Dystrophy in a Vietnamese Family

Diagnostics, 2020
Muscular dystrophies are a group of heterogeneous clinical and genetic disorders. Two siblings presented with characteristics like muscular dystrophy, abnormal white matter, and elevated serum creatine kinase level.
Ngoc-Lan Nguyen, Can Thi Bich Ngoc, Chi Dung Vu, Thi Thu Huong Nguyen, Huy Hoang Nguyen   +4 more
doaj   +1 more source

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis, Maria Elena Silva, Alerie G. de la Fuente, Fernando de Castro, Francisco J. Rivera   +4 more
wiley   +1 more source

Integrative multi‐omics analysis prioritizes DPEP1 as a genetically supported candidate associated with skin cancer risk

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Flowchart of the study design outlining target identification, validation, and subsequent functional and translational characterization. Abstract Background Skin cancer (SC) is among the most prevalent malignancies, yet causal circulating proteins and tractable therapeutic targets remain poorly defined.
Fan Shen, Yongkai Yu, Zongfeng Liao, Liye Mao, Qianyun Wang, Wanju Wang, Yuanhui Liu, Ling Li   +7 more
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang, Yiqiong Song, Ziyang Wang, Ke Chao, Lifeng Li, Xu Zhang, Xiaoran Duan, Chenglong Yu, Ruyue Xue, Jie Zhao   +9 more
wiley   +1 more source

Current understanding and treatment of cardiac and skeletal muscle pathology in laminin-α2 chain-deficient congenital muscular dystrophy

The Application of Clinical Genetics, 2019
Quynh Nguyen,*,1 Kenji Rowel Q Lim,*,1 Toshifumi Yokota,1,21Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 2The Friends of Garrett Cumming Research & Muscular Dystrophy Canada,
Nguyen Q, Lim KRQ, Yokota T
doaj  

Congenital Myopathies and Muscular Dystrophies: A Single Tertiary Center Experience and Factors Associated With Long‐Term Outcomes

Muscle &Nerve, Volume 74, Issue 1, Page 121-130, July 2026.
ABSTRACT Introduction/Aims Data on respiratory, feeding, ambulatory outcomes and prognostic factors for congenital myopathies (CM) and congenital muscular dystrophies (CMD) remain limited. Therefore, in this study, we report the characteristics of a large single‐center cohort of patients with CM and CMD, focusing on long‐term outcomes and aiming to ...
Can Ozlu, Margaret McGurn, Susan Iannaccone, Zurisadai Gonzalez Castillo, Kaitlin Batley   +4 more
wiley   +1 more source

How Lama2-deficiency impacts myoblast differentiation in a mouse model for LAMA2-congenital muscular dystrophy

, 2022
Tese de Mestrado, Biologia Evolutiva e do Desenvolvimento, 2022, Universidade de Lisboa, Faculdade de ...
openaire   +1 more source