Results 211 to 220 of about 689,449 (295)

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito   +6 more
wiley   +1 more source

Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management

open access: yesPest Management Science, EarlyView.
Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela   +4 more
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve   +6 more
wiley   +1 more source

Author Correction: Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks. [PDF]

open access: yesLab Anim (NY)
Lamb J   +16 more
europepmc   +1 more source

Characteristics of diabatically influenced cyclones with high wind damage potential in Europe

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Diabatic processes contribute, on average, 26% to the intensification of European winter storms, with diabatically driven cyclones exhibiting steeper deepening rates, stronger wind gusts, and increased precipitation. These storms are linked to enhanced warm conveyor belt (WCB) activity and develop in a warmer environment with elevated lower ...
Svenja Christ   +2 more
wiley   +1 more source

Impact of small‐scale gravity waves on tracer transport

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
We extend a gravity wave (GW) parametrization to calculate the tracer transport due to the GW–Stokes drift and next‐order effects, where the approach is validated by comparing coarse‐resolution simulations with parametrized GWs to high‐resolution, wave‐resolving reference simulations.
Irmgard Knop   +2 more
wiley   +1 more source

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