Results 51 to 60 of about 14,639 (283)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

No solvable lambda-value term left behind [PDF]

open access: yesLogical Methods in Computer Science, 2016
In the lambda calculus a term is solvable iff it is operationally relevant. Solvable terms are a superset of the terms that convert to a final result called normal form.
Á. García-Pérez, P. Nogueira
doaj   +1 more source

Gems of Corrado B\"ohm [PDF]

open access: yesLogical Methods in Computer Science, 2020
The main scientific heritage of Corrado B\"ohm consists of ideas about computing, concerning concrete algorithms, as well as models of computability. The following will be presented. 1. A compiler that can compile itself. 2.
Henk P. Barendregt
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Java & Lambda: a Featherweight Story [PDF]

open access: yesLogical Methods in Computer Science, 2018
We present FJ&$\lambda$, a new core calculus that extends Featherweight Java (FJ) with interfaces, supporting multiple inheritance in a restricted form, $\lambda$-expressions, and intersection types.
Lorenzo Bettini   +4 more
doaj   +1 more source

GLC actors, artificial chemical connectomes, topological issues and knots [PDF]

open access: yes, 2013
Based on graphic lambda calculus, we propose a program for a new model of asynchronous distributed computing, inspired from Hewitt Actor Model, as well as several investigation paths, concerning how one may graft lambda calculus and knot ...
Buliga, Marius, Kauffman, Louis H.
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Evaluating functions as processes [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2013
A famous result by Milner is that the lambda-calculus can be simulated inside the pi-calculus. This simulation, however, holds only modulo strong bisimilarity on processes, i.e. there is a slight mismatch between beta-reduction and how it is simulated in
Beniamino Accattoli
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Standardization and Conservativity of a Refined Call-by-Value lambda-Calculus [PDF]

open access: yesLogical Methods in Computer Science, 2017
We study an extension of Plotkin's call-by-value lambda-calculus via two commutation rules (sigma-reductions). These commutation rules are sufficient to remove harmful call-by-value normal forms from the calculus, so that it enjoys elegant ...
Giulio Guerrieri   +2 more
doaj   +1 more source

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