Results 71 to 80 of about 230,472 (297)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

open access: yesFEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar   +11 more
wiley   +1 more source

Light Logics and the Call-by-Value Lambda Calculus [PDF]

open access: yesLogical Methods in Computer Science, 2008
The so-called light logics have been introduced as logical systems enjoying quite remarkable normalization properties. Designing a type assignment system for pure lambda calculus from these logics, however, is problematic.
Paolo Coppola   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

A correspondence between rooted planar maps and normal planar lambda terms [PDF]

open access: yesLogical Methods in Computer Science, 2015
A rooted planar map is a connected graph embedded in the 2-sphere, with one edge marked and assigned an orientation. A term of the pure lambda calculus is said to be linear if every variable is used exactly once, normal if it contains no beta-redexes ...
Noam Zeilberger, Alain Giorgetti
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

The Vectorial $\lambda$-Calculus

open access: yesCoRR, 2013
Comment: Long and corrected version of arXiv:1012.4032 (EPTCS 88:1-15), to appear in Information and ...
Pablo Arrighi   +2 more
openaire   +2 more sources

Proving Soundness of Extensional Normal-Form Bisimilarities [PDF]

open access: yesLogical Methods in Computer Science, 2019
Normal-form bisimilarity is a simple, easy-to-use behavioral equivalence that relates terms in $\lambda$-calculi by decomposing their normal forms into bisimilar subterms.
Dariusz Biernacki   +2 more
doaj   +1 more source

FUNDIO: a lambda-calculus with letrec, case, constructors, and an IO-interface : approaching a theory of unsafePerformIO [PDF]

open access: yes, 2003
This paper proposes a non-standard way to combine lazy functional languages with I/O. In order to demonstrate the usefulness of the approach, a tiny lazy functional core language FUNDIO , which is also a call-by-need lambda calculus, is investigated. The
Schmidt-Schauß, Manfred
core  

Polynomial Time in the Parametric Lambda Calculus [PDF]

open access: yes, 2015
In this paper we investigate Implicit Computational Complexity via the parametric lambda calculus of Ronchi Della Rocca and Paolini. We show that a particular instantiation of the set of input values leads to a characterization of polynomial time ...
Redmond, Brian F.
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

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