Results 31 to 40 of about 1,035,663 (297)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Tsunami Damping due to Bottom Friction Considering Flow Regime Transition and Depth-Limitation in a Boundary Layer

open access: yesJournal of Marine Science and Engineering, 2022
According to recent investigations on bottom boundary layer development under tsunami, a wave boundary can be observed even at the water depth of 10 m, rather than a steady flow type boundary layer.
Hitoshi Tanaka   +2 more
doaj   +1 more source

A laminar vortex interacting with a premixed flame - Regimes of interaction [PDF]

open access: yes30th Aerospace Sciences Meeting and Exhibit, 1992
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/76682/1/AIAA-1992-235-112 ...
Roberts, William L.   +2 more
openaire   +1 more source

The laminar boundary layer regime for natural convection of air in a square cavity [PDF]

open access: yes, 1990
Numerical predictions are obtained for laminar natural convection of air in a square two dimensional cavity at high Rayleigh numbers. Proper resolution of the core reveals weak multi-cellular structure which varies in a complex manner as the effects of ...
Kelson, Neil A.
core  

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

open access: yesAdvanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora   +4 more
wiley   +1 more source

Heat transfer and flow field in a circular twisted channel

open access: yesMATEC Web of Conferences, 2018
In the present paper, along with experimental study, computational fluid dynamics analysis is performed, using the transition SST model which can predict the change of flow regime from laminar through transition to turbulent.
Bhattacharyya Suvanjan   +3 more
doaj   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

open access: yesAdvanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares   +3 more
wiley   +1 more source

Analysis of laminar and turbulent natural, mixed and forced convection in cavities by heatlines

open access: yesArchives of Mechanics, 2016
Laminar and turbulent convective heat transfer in a ventilated and non-ventilated cavity was analyzed by heatlines. Heatlines show that in non-ventilated cavities it is possible to estimate the energy path using the streamlines for turbulent flow regime.
I. Hernández-López   +4 more
doaj   +1 more source

Flexural Behavior of 3D‐Printed Porous Bouligand‐Structured Polymers: Influence of Pitch Angle and Porosity

open access: yesAdvanced Engineering Materials, EarlyView.
This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil   +2 more
wiley   +1 more source

Mean flow of turbulent–laminar patterns in plane Couette flow [PDF]

open access: yes, 2007
A turbulent–laminar banded pattern in plane Couette flow is studied numerically. This pattern is statistically steady, is oriented obliquely to the streamwise direction, and has a very large wavelength relative to the gap. The mean flow, averaged in time
DWIGHT BARKLEY   +3 more
core   +1 more source

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