Results 51 to 60 of about 506,000 (289)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Initiation and propagation mechanisms of progressive crushing in carbon-epoxy laminated plates [PDF]

open access: yes, 2008
This article presents original experiments that enhance the understanding of the mechanisms that drive the progressive crushing of fiber-reinforced laminated composite materials and their energy absorption capability.
Guillon, Damien   +5 more
core  

Constructing a “brick and mortar” structure to synchronously strengthen the mechanical and tribological properties of fabric laminated composites by isocyanate functionalized carbon fiber powders

open access: yesFriction
Fabric laminated composites with excellent mechanical strength and brake stability are now developed as promising wet friction materials. However, facing the serious challenge of persistent operation under harsh conditions, the resistance and ...
Jifeng Yan   +5 more
doaj   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

open access: yesAdvanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora   +4 more
wiley   +1 more source

Analytical modelling of laminated composites

open access: yesComposites Science and Technology, 1993
This paper presents a unique approach to the analysis of thick laminated composites by presenting two simple finite element methods. The first uses the predictor corrector technique to extend the simple Mindlin-type element to achieve greater accuracy, and the second develops a new least squares element which can approximate a C(1) continuous element ...
Jeffrey V. Kouri, Satya N. Atluri
openaire   +2 more sources

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

open access: yesAdvanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares   +3 more
wiley   +1 more source

Flexural Behavior of 3D‐Printed Porous Bouligand‐Structured Polymers: Influence of Pitch Angle and Porosity

open access: yesAdvanced Engineering Materials, EarlyView.
This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil   +2 more
wiley   +1 more source

Workflow for Design of Experiments‐Based Modeling of Species Transport and Growth Kinetics in GaN Hydride Vapor Phase Epitaxy

open access: yesAdvanced Engineering Materials, EarlyView.
A novel workflow for investigating hydride vapor phase epitaxy for GaN bulk crystal growth is proposed. It combines Design of experiments (DoE) with physical simulations of mass transport and crystal growth kinetics, serving as an intermediate step between DoE and experiments.
J. Tomkovič   +7 more
wiley   +1 more source

Material characterisation and calibration of a meso-mechanical damage model for braid reinforced composites [PDF]

open access: yes, 2006
Cost effective braid reinforced composites are a potential substitute for metals in many automotive structural applications where good mechanical performance combined with high energy absorption are of special interest.
M.R.C. Fouinneteau   +3 more
core   +1 more source

Palliatives for Low Velocity Impact Damage in Composite Laminates

open access: yesAdvances in Materials Science and Engineering, 2017
Fibre reinforced polymer laminated composites are susceptible to impact damage during manufacture, normal operation, maintenance, and/or other stages of their life cycle.
Mubarak Ali   +2 more
doaj   +1 more source

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