Results 201 to 210 of about 1,656,943 (332)

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma   +15 more
wiley   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

open access: yesAdvanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu   +20 more
wiley   +1 more source

Dual‐Modulated Vertically Stacked Transistors With Fully Laminated Plate‐Type Architecture Featuring Nanoscale Channel Length

open access: yesAdvanced Science, EarlyView.
A new vertical transistor design with a dual‐modulation strategy is proposed to overcome the limitations of conventional transistors. This architecture uses a micro‐hole patterned electrode and a graphene electrode to enhance channel control and incorporates a leakage blocking layer to suppress off‐state current.
Goeun Pyo   +6 more
wiley   +1 more source

Compliant Polymeric Sheet‐Based Heat Exchangers

open access: yesAdvanced Science, EarlyView.
This work presents flexible, transparent, and deployable polymer heat exchangers that achieve a heat transfer capacity per cost up to 4x higher than the state of the art, surpassing both metal and other polymer counterparts. The tube‐on‐tube design enables efficient heat transfer without flow occlusion, while the lightweight, corrosion‐resistant, and ...
Richard J. Fontenot   +5 more
wiley   +1 more source

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