Results 91 to 100 of about 5,341 (243)
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Compliant Polymeric Sheet‐Based Heat Exchangers
Advanced Science, EarlyView.This work presents flexible, transparent, and deployable polymer heat exchangers that achieve a heat transfer capacity per cost up to 4x higher than the state of the art, surpassing both metal and other polymer counterparts. The tube‐on‐tube design enables efficient heat transfer without flow occlusion, while the lightweight, corrosion‐resistant, and ...
Richard J. Fontenot +5 more
wiley +1 more source
The Glue Joint Strength of Laminated Timber Decking made from Three Malaysian Hardwood Species [PDF]
, 1984 Glue joint strengths of laminated timber decking made from three Malaysian hardwood species i.e. Kempas (Koompassia malaccensis), Nemesu (Shorea pauciflora) and Seraya (Shorea curtisii) were evaluated. Single and mixed species laminations were produced
Sahri, Mohd Hamami
core
Advanced Science, EarlyView.In this study, the evolution of the lithium (Li)/polymer interface is compared in a realistic pouch cell configuration, either in Li/Li symmetric cell or in full Li/LiFePO4${\rm LiFePO}_4$ batteries thanks to X‐ray micro‐tomography. While Li/Li symmetric cells are the reference cell for probing the interface stability, results demonstrated that the end‐
Lucile Magnier +8 more
wiley +1 more source
Advanced Science, EarlyView.This work successfully fabricated ion‐conductive hydrogels with low hysteresis and high conductivity using 3D printing technology. By adjusting the component ratios, the properties of the hydrogels can be tuned to meet diverse sensing requirements. Finally, a multimodal sensing sign language recognition system was constructed based on this hydrogel ...
Quan Hu +9 more
wiley +1 more source
Numerical, Theoretical, and Experimental Analysis of LVL-CFRP Sandwich Structure. [PDF]
Materials (Basel), 2023 Bakalarz MM, Kossakowski PG.
europepmc +1 more source
Economic Contribution of the Agricultural Sector to the Arkansas Economy in 2009 [PDF]
, 2011 This report is the sixth in a series of reports examining agriculture’s economic contribution on the Arkansas economy. Utilizing data from the United States Bureau of Economic Analysis (BEA), USDA Economic Research Service (ERS), USDA National ...
McGraw, Katherine +2 more
core +1 more source