Results 191 to 200 of about 15,070 (269)

Circadian Clock Dysfunction Exacerbate Autistic‐Like Behaviour and Wnt/β‐Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Between 50% and 80% of children diagnosed with Autism Spectrum Disorder (ASD) are estimated to experience sleep disturbances, highlighting the importance of exploring the role of the circadian clock in ASD development. Previous studies have identified a potential link between Bmal1 deficiency and ASD in mouse models.
Yuxing Zhang   +6 more
wiley   +1 more source

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Platinum‐based chemotherapy remains a cornerstone of glioma treatment, yet resistance driven by the Fanconi anaemia (FA) DNA repair pathway limits efficacy. Here, we identified betulinic acid (BA) as a potent inhibitor of FA pathway activation.
Yifeng Bao, Maode Wang
wiley   +1 more source

Cross‐Species Transfer of the Maize NAM‐ATAF1/2‐CUC2 Transcription Factor ZmNAC2 Confers Disease Resistance in Transgenic Rice Without a Yield Penalty

open access: yesMolecular Plant Pathology, Volume 27, Issue 1, January 2026.
The maize ZmNAC2 gene, which encodes an NAM‐ATAF1/2‐CUC2 (NAC2) transcription factor, confers broad‐spectrum disease resistance (BSR) when introduced into rice without compromising yield. BSS, broad‐spectrum susceptibility. ABSTRACT Rice is a staple crop feeding over half of the global population, yet it faces severe yield losses due to devastating ...
Xinying Gao   +7 more
wiley   +1 more source

Troubling the Waters: Black African Christian Presence and the Reshaping of Christianity in Canada

open access: yesReligion Compass, Volume 20, Issue 1, January/February 2026.
ABSTRACT This article explores the histories of Christians of African descent in Canada, challenging Eurocentric narratives that have rendered their religious contributions invisible. Using polycentric framework, it examines how historic Black Christian communities—from Black Loyalists and Refugees in Nova Scotia to congregations across Ontario and ...
James Kwateng‐Yeboah
wiley   +1 more source

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

open access: yesThe Journal of Physiology, Volume 604, Issue 1, Page 129-144, 1 January 2026.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista   +2 more
wiley   +1 more source

Robinia pseudoacacia L. Flower Exosome‐Like Nanoparticles (RFELNs) Activate AhR/IL‐22 to Relieve Intestinal Barrier Dysfunction Through Regulating Gut Microbiota‐Interrelated Tryptophan Metabolism in Ulcerative Colitis Mice

open access: yesMediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Intestinal barrier dysfunction is a key driver of ulcerative colitis (UC) recurrence and chronic persistence. Modulating group 3 innate lymphoid cells (ILC3) activity and tryptophan‐derived metabolites is crucial for enhancing mucosal repair in UC. Robinia pseudoacacia L. flower exosome‐like nanoparticles (RFELNs) could ameliorate intestinal
Feihan Shen   +8 more
wiley   +1 more source

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