Results 271 to 280 of about 18,044 (328)

Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Astrocyte senescence contributes to brain aging and neurodegeneration, yet human‐relevant models remain scarce. We developed a doxorubicin‐based protocol that reliably induces senescence in murine and human astrocytes. Treated cells showed nuclear enlargement, reduced proliferation (BrdU), and increased markers of senescence (p21, β‐galactosidase), DNA
Mariana Marques, Lívia de Sá Hayashide, Pedro Amorim, Beatriz Martins Fernandes, Ana Paula Bergamo Araujo, Daniel Fernandes Messor, Vitor Emanuel Leocadio, Bruna Pessoa, João Bastos Lima Pacca Corrêa, Cristopher Villablanca, René L. Vidal, Christian González‐Billault, Isadora Matias, Flávia Carvalho Alcantara Gomes, Luan Pereira Diniz   +14 more
wiley   +1 more source

LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions. [PDF]

Nucleic Acids Res
Ferraioli S, Sarigol F, Prakash C, Filipczak D, Foisner R, Naetar N.   +5 more
europepmc   +1 more source

New Click on the Block: Photocaged Hydroxylamine, an Addition to the Light‐Activatable Bioorthogonal Toolbox

Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.
The retro‐Cope bioorthogonal reactivity of hydroxylamines was disabled transiently with a coumarin photolabile protecting group, which could be recovered upon removal of the protecting group by a short, 400 nm light illumination. Light‐controlled recovery of reactivity was demonstrated in bioorthogonal fluorescent labeling schemes of intracellular ...
Krisztina Németh, Flóra Horváth, Ágnes Szatmári, Evelin Albitz, Péter Kele, Gergely B. Cserép   +5 more
wiley   +1 more source

A dynamic barrier: remodeling of the nuclear envelope during closed mitosis in malaria parasites. [PDF]

mSphere
Absalon S.
europepmc   +1 more source

Mistargeting of B-Type Lamins at the End of Mitosis

, 2001
Rikke L. Steen, Philippe Collas
openalex   +1 more source

Aging and Altered Gravity: A Cellular Perspective

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven, Jack J. W. A. van Loon   +1 more
wiley   +1 more source

A role for nuclear lamins in nuclear envelope assembly

, 2001
Reynold I. Lopez‐Soler, Robert D. Moir, Timothy P. Spann, Reimer Stick, Robert D. Goldman   +4 more
openalex   +1 more source

Vasopressin‐Sensitive Aqp2 Regulation Mediated by the TAZ‐NR4A1 Axis in Renal Collecting Duct Cells

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The TAZ‐NR4A1 axis was identified as a critical regulator of vasopressin‐induced AQP2 expression, essential for water homeostasis. Conditional TAZ‐knockout mice showed polyuria and a significant decrease in AQP2 expression in collecting ducts. In mpkCCDc11 cells, TAZ knockdown significantly impaired vasopressin‐mediated AQP2 expression independently of
Hong Seok Choi, Hyo‐Ju Jang, Wan‐Young Kim, Sun Ah Park, Euijung Park, Hyun Jun Jung, Tae‐Hwan Kwon   +6 more
wiley   +1 more source

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases. [PDF]

Front Cell Dev Biol
Wu T, Xu H, Cheng L, Wu R, Guo F, Chen X.   +5 more
europepmc   +1 more source

Role of the cytoskeleton in cellular reprogramming: effects of biophysical and biochemical factors. [PDF]

Front Mol Biosci
Momotyuk E, Ebrahim N, Shakirova K, Dashinimaev E.   +3 more
europepmc   +1 more source